| 摘要: |
| ［摘要］ 目的 分析亚甲基四氢叶酸还原酶（MTHFR）、蛋白C（PROC）的基因多态性与恶性肿瘤患者发生静脉血栓栓塞症（VTE）的关联性。方法 回顾性分析2023年11月14日至2024年2月14日新疆医科大学附属肿瘤医院收治的227例恶性肿瘤患者的临床资料，根据VTE发生情况将其分为VTE组（47例）和非VTE组（180例）。比较两组PROC基因（rs199469469位点）和MTHFR基因（rs1801133位点）多态性及其他临床资料，采用多因素logistic回归分析影响恶性肿瘤患者发生VTE的因素。结果 VTE组D-二聚体水平以及有糖尿病史的人数比例高于非VET组，差异有统计学意义（P<0.05）。两组MTHFR基因rs1801133位点的基因型分布差异有统计学意义（P<0.05），VTE组MTHFR基因rs1801133位点的A等位基因频率显著高于非VET组［53.19%（50/94） vs 38.89%（140/360）， χ2=3.945，P=0.047］。两组PROC基因rs199469469位点的基因型比较差异无统计学意义（P>0.05）。多因素logistic回归分析结果显示，较高的D-二聚体水平［OR（95%CI）=1.436（1.213～1.696）］、有糖尿病史［OR（95%CI）=2.318（1.125～6.808）］，以及MTHFR基因rs1801133位点的基因型为AA型［OR（95%CI）=1.927（1.459～3.751）］是促进恶性肿瘤患者发生VTE的独立危险因素（P<0.05）。结论 MTHFR基因rs1801133位点多态性与恶性肿瘤患者发生VTE存在关联性，PROC基因rs199469469位点多态性与VTE发生的关联性不显著。 |
| 关键词: 恶性肿瘤 静脉血栓栓塞症 亚甲基四氢叶酸还原酶 蛋白C 基因多态性 |
| DOI：10.3969/j.issn.1674-3806.2025.01.06 |
| 分类号:R 730.6 |
| 基金项目:国家自然科学基金项目（编号：82360468）；新疆自然科学基金项目（编号：2024D01E28） |
|
| Analysis on the correlation between MTHFR and PROC gene polymorphisms and the occurrence of venous thromboembolism in patients with malignant tumors |
|
CUI Yingxue1, NURBIA Rexiti1, HE Man2, ZHU Zihui2, HOU Xueping2, WANG Yuying2, JIANG Weihua2
|
|
1.The Third Clinical College of Xinjiang Medical University, Urumqi 830011, China; 2.The Second Ward of Breast Surgery, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, China
|
| Abstract: |
| ［Abstract］ Objective To analyze the correlation between methylenetetrahydrofolate reductase(MTHFR) and protein C(PROC) gene polymorphisms and the occurrence of venous thromboembolism(VTE) in patients with malignant tumors. Methods The clinical data of 227 patients with malignant tumors who were admitted to Affiliated Cancer Hospital of Xinjiang Medical University from November 14, 2023 to February 14, 2024 were retrospectively analyzed. According to the occurrence of VTE, the patients were divided into VTE group(47 cases) and non-VTE group(180 cases). The polymorphisms of PROC gene(rs199469469 locus) and MTHFR gene(rs1801133 locus) and the other clinical data were compared between the two groups. Multivariate logistic regression was used to analyze the factors affecting the occurrence of VTE in patients with malignant tumors. Results The level of D-dimer and the proportion of the patients with a history of diabetes in the VTE group were higher than those in the non-VTE group, and the differences were statistically significant(P<0.05). There was a significant difference in the genotype distribution of rs1801133 locus of MTHFR gene between the two groups(P<0.05). The frequency of A allele of rs1801133 locus of MTHFR gene in the VTE group was significantly higher than that in the non-VTE group［53.19%(50/94)vs 38.89%(140/360), χ2=3.945, P=0.047］. There was no significant difference in the genotype of rs199469469 locus of PROC gene between the two groups(P>0.05). The results of multivariate logistic regression analysis showed that higher D-dimer level［OR(95%CI)=1.436(1.213-1.696)］, a history of diabetes［OR(95%CI)=2.318(1.125-6.808)］, AA genotype of rs1801133 locus of MTHFR gene［OR(95%CI)=1.927(1.459-3.751)］ were independent risk factors for promoting the occurrence of VTE in patients with malignant tumors(P<0.05). Conclusion The polymorphisms of rs1801133 locus of MTHFR gene are correlated with the occurrence of VTE in malignant tumor patients, but the polymorphisms of rs199469469 locus of PROC gene are not significantly correlated with the occurrence of VTE. |
| Key words: Malignant tumor Venous thromboembolism(VTE) Methylenetetrahydrofolate reductase(MTHFR) Protein C(PROC) Gene polymorphism |
