| 摘要: |
| ［摘要］ 目的 评估枸缘酸他莫昔芬治疗特发性少弱精子症的临床价值。方法 分析2012-01～2014-12间276例特发性少弱精子症患者的临床资料，根据治疗方案的不同分为治疗组和对照组，其中治疗组148例，采用枸缘酸他莫昔芬、维生素E、三磷酸腺苷二钠治疗，对照组128例单纯采用维生素E和三磷酸腺苷二钠治疗，经过3个月的治疗周期后，观察患者的精子参数改善情况。结果 两组患者的精子参数在治疗前组间比较差异无统计学意义（P>0.05），经过3个月的治疗后，两组患者的每次精子总数和前向运动精子百分率均比治疗前高，差异有统计学意义（P<0.01）。治疗组的每次射精精子总数低于对照组，而前向运动精子百分率高于对照组，差异均有统计学意义（P<0.01）。结论 枸缘酸他莫昔芬能够改善特发性少弱精子症患者的精子参数，但对精子总数的提高没有对照组明显，临床中对于少精子症患者的使用值得进一步商榷。 |
| 关键词: 枸缘酸他莫昔芬 少弱精子症 临床价值 |
| DOI：10.3969/j.issn.1674-3806.2016.12.19 |
| 分类号:R 698+.2 |
| 基金项目: |
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| The clinical value of tamoxifen citrate in the treatment of idiopathic oligoasthenospermia |
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LI Gang, CHEN Wei-bin, LIU Huang
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The Second Maternal and Child Health Hospital of Huizhou City, Guangdong 516000, China
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| Abstract: |
| ［Abstract］ Objective To evaluate the clinical value of tamoxifen citrate in the treatment of idiopathic oligoasthenospermia.Methods The clinical data of 276 patients with the idiopathic oligoasthenospermia from January 2012 to December 2014 were retrospectively analyzed. All of these 276 patients were divided into two groups according to the different treatment methods. The treatment group(n=148) was treated with the triple therapy of tamoxifen citrate along with vitamin E and ATP, and the control group(n=128) was treated with the usual therapy of vitamin E and ATP only. The parameters of sperms were compared between the two groups 3 months after the treatment.Results After the treatment, the total number of sperm and the forward movement percentage of sperms were significantly elevated than those before the treatment in the two groups. There were no significant differences between the two groups before the treatment(P>0.05). However, the total number of sperms in the treatment group was significantly less than that in the control group（P<0.01）, and the forward movement percentage of sperms in the treatment group was elevated than that in the control group（P<0.01）.Conclusion Tamoxifen citrate can improve the parameters of sperms in patients with idiopathic oligoasthenospermia, but can′t significantly increase the total number of sperms, which needs further study to evaluate its clinical application. |
| Key words: Tamoxifen citrate Oligoasthenospermia Clinical value |
