| 摘要: |
| ［摘要］ 目的 分析黄石市620例女性宫颈病变与宫颈人乳头瘤病毒（HPV）亚型的关系，为宫颈癌防治及宫颈HPV疫苗研制提供数据支持。方法 选取2015-01～2015-12在黄石市妇幼保健院进行宫颈癌筛查女性6 500例，结合液基薄层细胞(TCT)、阴道镜和宫颈活检结果进行分组研究。结果 HPV感染阳性率为25.23%；根据病检结果：慢性宫颈炎、宫颈上皮内瘤样病变（CIN）Ⅰ级、CINⅡ/Ⅲ级、宫颈癌HPV感染率分别为37.50%、60.00%、83.33%、100.00%。其中高危型HPV16（33.87%）、高危型HPV52（14.52%）、低危型HPV43（6.45%）、低危型HPV42（6.45%）所占比率最高，而单一感染占79.55%，≤30岁感染率为40.28%。结论 黄石地区最多见的感染宫颈HPV亚型为高危型HPV16、HPV52及低危型HPV43、HPV42，且随着宫颈病变程度的增加，宫颈HPV的阳性率也随之增加，以单一感染为主。宫颈HPV感染有年轻化的趋势。 |
| 关键词: 宫颈病变 人乳头瘤病毒亚型 感染率 |
| DOI：10.3969/j.issn.1674-3806.2018.04.17 |
| 分类号:R 71 |
| 基金项目: |
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| Relationship between cervical lesions and cervical HPV subtype distribution in Huangshi city |
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HU Jing, LU Na
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Department of Women′s Health Care, Huangshi Maternity and Child Healthcare Hospital, Hubei 435000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the relationship between cervical lesions and cervical papillomavirus(HPV) subtypes in Huangshi area, and to provide the data for cervical cancer prevention and development of cervical HPV vaccine.Methods 6 500 cases of cervical cancer screening were selected in Huangshi Maternity and Child Healthcare Hospital, and the results were compared with TCT, colposcopy and cervical biopsy.Results The positive rate of HPV infection was 25.23%; According to the pathological test results, the positive infection rates of HPV chronic cervicitis,cervical intraepithelial neoplasia(CIN)gradeⅠ, CINⅡ/Ⅲ and cervical cancer were 37.50%, 60.00%, 83.33% and 100.00% respectively.High-risk HPV42(33.87%), high-risk HPV52(14.52%), low-risk HPV43(6.45%) and low-risk HPV42(6.45%) were the highest percentage, while a single infection accounted for 79.55%. The HPV infection rate at the age≤30 years was 40.28%.Conclusion High-risk HPV16, 52 and low-risk HPV43, 42 are the common subtypes in cervical lesions in Huangshi area. With increase in cervical lesions, the positive infection rate of cervical HPV also increases, which is primarily in a single infection. Cervical HPV infection becomes an increasingly younger trend. |
| Key words: Cervical lesions Cervical papillomavirus(HPV) subtypes Infection rate |
