| 摘要: |
| ［摘要］ 目的 研究孕期血清维生素A、D、E水平与孕期贫血相关性。方法 选取2017-01～2019-01于该院接受产检1 000例妊娠期女性，根据血红蛋白（HGB）水平分为贫血组（n=600，HGB<100 g/L）和无贫血组（n=400，HGB≥100 g/L），比较两组贫血三项（铁蛋白、叶酸、维生素B12）、血常规指标［HGB、平均红细胞体积（MCV）、红细胞压积（HCT）］水平及血清维生素A、D、E水平，比较两组血清维生素A、D、E水平异常情况（缺乏率与过量率），分析血清维生素A、D、E与贫血三项、血常规指标的相关性，以及贫血组随访情况。结果 贫血组铁蛋白、叶酸、维生素B12、HGB、HCT水平显著低于无贫血组（P<0.05）；贫血组血清维生素A、D水平显著低于无贫血组（P<0.05）；贫血组维生素A、D缺乏率显著高于无贫血组（P<0.05）；两组维生素E缺乏、过量分布情况比较差异无统计学意义（P>0.05）。血清维生素A、D与铁蛋白、HGB呈正相关（P<0.05），血清维生素A、D、E与叶酸、维生素B12、MCV、HCT无明显相关性（P>0.05）。对贫血组给予对应维生素合理化用药指导、膳食调整等指导后，516例分娩前HGB恢复至≥100 g/L。结论 血清维生素A、D与铁蛋白、HGB呈正相关，维生素E水平与孕期贫血发生的关联性较小。 |
| 关键词: 孕期 维生素A 维生素D 维生素E 贫血 相关性 |
| DOI：10.3969/j.issn.1674-3806.2020.03.10 |
| 分类号:R 714 |
| 基金项目:中华国际科学交流基金会项目（编号：Z2019LHNB005） |
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| Study on correlation between serum levels of vitamin A, D, E and anemia during pregnancy |
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ZHOU Li-juan, GONG Jun
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Department of Obstetrics, Xuchang Central Hospital Affiliated to Henan University of Science and Technology, Henan 461000, China
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| Abstract: |
| ［Abstract］ Objective To study the correlation between serum levels of vitamin A, D, E and anemia during pregnancy. Methods One thousand pregnant women receiving routine examination of parturient in Xuchang Central Hospital were selected during January 2017 and January 2019 and were divided into anemia group(n=600, HGB<100 g/L) and non-anemia group(n=400, HGB≥100 g/L) according to their different levels of hemoglobin(HGB). The three items of anemia(including ferritin, folic acid and vitamin B12), blood routine indexes［HGB, mean corpuscular volume(MCV) and hematocrit(HCT)］, the serum levels of vitamin A, D and E were compared between the two groups. The abnormal levels of serum vitamin A, D and E(deficiency rate and excessive rate) were compared between the two groups. The correlation between serum levels of vitamin A, vitamin D and vitamin E and three indexes of anemia and blood routine indexes was analyzed. The follow-up results of the anemia group were analyzed. Results The levels of ferritin, folic acid, vitamin B12, HGB and HCT in the anemia group were significantly lower than those in the non-anemia group(P<0.05). The serum levels of vitamin A and vitamin D in the anemia group were significantly lower than those in the non-anemia group(P<0.05). The deficiency rates of vitamin A and vitamin D in the anemia group were significantly higher than those in the non-anemia group(P<0.05). There were no significant differences in the distributions of vitamin E deficiency and vitamin E excess between the two groups(P>0.05). The serum levels of vitamin A and vitamin D were positively correlated with ferritin and HGB(P<0.05). There was no significant correlation between serum vitamin A, vitamin D, vitamin E and folic acid, vitamin B12, MCV, HCT(P>0.05). In the anemia group, the rational uses of vitamins and dietary adjustment were given, and the HGB of 516 cases recovered to ≥100 g/L before delivery. Conclusion Serum vitamin A and vitamin D are positively correlated with ferritin and HGB. The level of vitamin E is less associated with anemia during pregnancy. |
| Key words: Pregnancy Vitamin A Vitamin D Vitamin E Anemia Correlation |
