| 摘要: |
| ［摘要］ 血红蛋白病是中国南方地区最常见的遗传性疾病之一。临床表现不一，有的没有表型，有的可出现不同程度的贫血，严重类型的患者需要输血或在妊娠期可导致胎儿流产和死胎。糖化血红蛋白是反映近2～3个月血糖控制水平的指标，作为糖尿病筛查和血糖控制情况的指标在临床广泛使用。近年多项研究显示，血红蛋白病对糖化血红蛋白检测值存在干扰，与采用的方法学有关。此外，有研究表明，毛细管电泳法糖化血红蛋白检测模式是一种新的血红蛋白病筛查方法。该文就血红蛋白病对糖化血红蛋白测定结果的影响作一综述。 |
| 关键词: 糖化血红蛋白 血红蛋白病 地中海贫血 异常血红蛋白 |
| DOI：10.3969/j.issn.1674-3806.2022.08.23 |
| 分类号:R 556 |
| 基金项目:广西卫生健康委科研课题（编号：Z20200076） |
|
| Effect of hemoglobinopathy on the determination results of glycosylated hemoglobin |
|
LI You-qiong, TIAN Mao
|
|
Center for Medical Genetics and Prenatal Diagnosis, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
|
| Abstract: |
| ［Abstract］ Hemoglobinopathy is the most common genetic disease in southern parts of China. The clinical manifestations of the disease vary from no phenotype to varying degrees of anemia, and the patients with severe types of hemoglobinopathy need blood transfusion or severe types of hemoglobinopathy can lead to fetal abortion and stillbirth during pregnancy. Glycosylated hemoglobin(HbA1c) is an indicator reflecting the level of glycemic control in the past 2-3 months. It is widely used in clinical practice as an indicator for screening diabetes mellitus and blood glucose control. In recent years, a number of studies have showed that hemoglobinopathy interferes with the detection value of HbA1c, which is related to the adopted methodology. In addition, studies have showed that the detection mode of HbA1c by capillary electrophoresis is a new screening method for hemoglobinopathy. This paper reviews the effect of hemoglobinopathy on the determination results of HbA1c. |
| Key words: Glycosylated hemoglobin(HbA1c) Hemoglobinopathy Thalassemia Abnormal hemoglobin |
