| 摘要: |
| ［摘要］ 目的 分析阻塞性冠心病（CAD）患者冠状动脉CT成像(CCTA)高危斑块特征和冠状动脉狭窄程度与冠状动脉血流储备分数异常的关联性。方法 回顾性分析2017年1月至2018年6月于河北北方学院附属第一医院行CCTA检查并确诊为CAD的139例患者临床资料，纳入205支冠状动脉，依据冠状动脉基于CT血流储备分数（FFRCI）值，将冠状动脉分为FFRCI异常组（FFRCI≤0.80，117支）和FFRCI正常组（FFRCI>0.80，88支）。比较两组高危斑块特征、冠状动脉狭窄程度，采用logistic回归分析冠状动脉狭窄程度、高危斑块特征对FFRCI异常的影响。结果 FFRCI异常组正性重构（PR）、低密度斑块（LAP）发生率显著高于FFRCI正常组（P<0.05）。两组冠状动脉狭窄程度比较差异有统计学意义（P<0.05）。冠状动脉重度狭窄、LAP、PR是促进FFRCI异常的独立危险因素（P<0.05）。结论 CCTA冠状动脉重度狭窄及LAP、PR与FFRCI异常发生密切相关，该特征有助于指导临床更好地识别血流动力学异常患者。 |
| 关键词: 阻塞性冠心病 计算机X线断层扫描 血流储备分数 高危斑块 |
| DOI：10.3969/j.issn.1674-3806.2024.01.09 |
| 分类号:R 541.4 |
| 基金项目:河北省医学科学研究课题计划项目（编号：20210342）；河北省张家口市科技计划项目（编号：2021030D） |
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| Analysis on CCTA high-risk plaque characteristics and correlation of the degree of coronary stenosis with abnormal coronary flow reserve fraction in patients with obstructive coronary artery disease |
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YANG Fei1, CHEN Rong2, YANG Zhixiang2, YANG Yue2, PANG Zhiying1, JIA Peng3, CUI Shujun1, WANG Dawei4
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1.Department of Medical Imaging, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China; 2.Hebei North University, Zhangjiakou 075000, China; 3.Beijing Huairou Hospital, Beijing 101400, China; 4.Department of Thoracic Surgery, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China
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| Abstract: |
| ［Abstract］ Objective To analyze coronary computed tomography angiography(CCTA) high-risk plaque characteristics and correlation of the degree of coronary stenosis with abnormal coronary flow reserve fraction in patients with obstructive coronary artery disease(CAD). Methods The clinical data of 139 patients who underwent CCTA and were diagnosed with CAD in the First Affiliated Hospital of Hebei North University from January 2017 to June 2018 were retrospectively analyzed, and 205 coronary arteries were enrolled. All the enrolled coronary arteries were divided into abnormal computed tomography(CT)-derived fractional flow reserve(FFRCI) group(FFRCI≤0.80, 117 vessels) and normal FFRCI group(FFRCI>0.80, 88 vessels) according to different values of FFRCI. The characteristics of high-risk plaques and the degree of coronary stenosis were compared between the two groups. The effects of the degree of coronary stenosis and the characteristics of high-risk plaques on FFRCI abnormalities were analyzed by using logistic regression. Results The incidence rates of positive remodeling(PR) and low attenuation plaque(LAP) in the abnormal FFRCI group were significantly higher than those in the normal FFRCI group(P<0.05). There was a statistically significant difference in the degree of coronary artery stenosis between the two groups(P<0.05). Severe coronary stenosis, LAP and PR were independent risk factors of promoting abnormal FFRCI(P<0.05). Conclusion CCTA severe coronary artery stenosis, LAP and PR are closely related to abnormal FFRCI, which is helpful to guide clinical practice to better identify patients with hemodynamic abnormalities. |
| Key words: Obstructive coronary artery disease(CAD) Computed tomography Fractional flow reserve(FFR) High-risk plaque |
