| 摘要: |
| ［摘要］ 目的 分析9例伴印戒细胞样形态肺腺癌的临床病理特征。方法 回顾性分析2013年1月至2019年12月川北医学院附属医院及南充市中心医院收治的9例伴印戒细胞样形态肺腺癌患者的临床资料，分析其病理、影像学和临床特征以及治疗方案和生存预后。结果 9例患者中男3例，女6例；年龄34～74岁，中位年龄53岁。TNM分期为Ⅰ期1例，Ⅱ期1例，Ⅲ期5例，Ⅳ期2例。印戒细胞组分的比例为10%～100%，4例为单纯印戒细胞成分肺腺癌。9例均表现为甲状腺转录因子-1（TTF-1）（+）和细胞角蛋白7（CK7）（+）/细胞角蛋白20（CK20）（-）免疫表型。5例患者行手术切除，3例患者接受非手术治疗，1例患者因肿瘤侵犯主支气管、肺动脉、上腔静脉和心包而失去手术机会。总体生存时间6～61个月。结论 伴印戒细胞样形态肺腺癌是一种罕见的腺癌类型，可表现出TTF-1（+）和CK7（+）/CK20（-）免疫表型，其诊断主要依靠病理学检查。该病目前尚无标准治疗方案，患者生存预后不佳，靶向治疗或有机会改善其预后。 |
| 关键词: 肺腺癌 印戒细胞 临床病理特征 生存预后 |
| DOI：10.3969/j.issn.1674-3806.2024.02.07 |
| 分类号:R 734.2 |
| 基金项目:四川省医学会项目（编号：2021HR24）；精准医学四川省重点实验室开放基金项目（编号：2022KF-03） |
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| Analysis on the clinicopathological features of 9 cases of lung adenocarcinoma with signet-ring cell-like morphology |
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HE Liping1,2, HE Fang1,2, GONG Haiying3, JIAN Shunhai4, WU Cailiang5, JIN Xiuli6, JIANG Li1,2
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1.Department of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China; 2.North Sichuan Medical College, Nanchong 637000, China; 3.Department of Respiratory Medicine, Guang′an People′s Hospital, Sichuan 638500, China; 4.Department of Pathology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China; 5.Department of Pathology, Nanchong Central Hospital, Sichuan 637000, China; 6.Department of Radiology, Nanchong Central Hospital, Sichuan 637000, China
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| Abstract: |
| ［Abstract］ Objective To analyze the clinicopathological features of 9 cases of lung adenocarcinoma with signet-ring cell-like morphology. Methods The clinical data of 9 cases of lung adenocarcinoma with signet-ring cell-like morphology who were admitted to Affiliated Hospital of North Sichuan Medical College and Nanchong Central Hospital from January 2013 to December 2019 were retrospectively analyzed, and their pathology, imageology and clinical features, treatment regimens and survival prognosis were analyzed. Results Among the 9 patients, there were 3 males and 6 females, aged 34-74 years, with a median age of 53 years. The patients′ TNM stages included stage Ⅰ in 1 case, stage Ⅱ in 1 case, stage Ⅲ in 5 cases and stage Ⅳ in 2 cases. The proportion of signet-ring cell components ranged from 10% to 100%, and 4 cases suffered from lung adenocarcinoma with simple signet-ring cell components. All the 9 cases showed the immunophenotypes of transcription termination factor-1(TTF-1)(+) and cytokeratin 7(CK7)(+)/cytokeratin 20(CK20)(-). Five patients underwent surgical resection, and 3 patients received non-surgical treatment, and 1 patient lost the opportunity for surgery due to the tumor invasion into the main bronchus, pulmonary artery, superior vena cava and pericardium. The overall survival time was 6-61 months. Conclusion Lung adenocarcinoma with signet-ring cell-like morphology is a rare type of adenocarcinoma that can exhibit the immunophenotypes of TTF-1(+) and CK7(+)/CK20(-) and the diagnosis of this disease mainly relies on pathological examination. At present, there is not a standard treatment regimen for this disease, and the survival prognosis of the patients is poor, and targeted therapy may have the opportunity to improve the patients′ prognosis. |
| Key words: Lung adenocarcinoma Signet-ring cell Clinicopathological feature Survival prognosis |
