| 摘要: |
| ［摘要］ 脓毒症心肌病是脓毒症引起的可逆性心肌损伤，是一种非缺血性急性心功能障碍，可显著增加脓毒症患者的病死率。β1受体阻滞剂具有抗应激、抗氧化、调节免疫和抑制细胞死亡及保护心肌的作用。该文对β1受体阻滞剂防治脓毒症心肌病作用的研究进展作一综述。 |
| 关键词: 脓毒症 脓毒症心肌病 β1受体阻滞剂 艾司洛尔 药理作用 |
| DOI：10.3969/j.issn.1674-3806.2024.02.20 |
| 分类号:R 453.9 |
| 基金项目:吴阶平医学基金会临床科研专项课题（编号：32067502021084） |
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| Research progress in the effect of β1-receptor blockers on prevention and treatment of sepsis-induced cardiomyopathy |
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HU Shenghui1, YAO Liying1, WEI Wei2, GAO Yan2
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1.Graduate School, the Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang 150001, China; 2.Department of Critical Care Medicine, the Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang 150001, China
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| Abstract: |
| ［Abstract］ Sepsis-induced cardiomyopathy(SIC) is a reversible myocardial injury caused by sepsis. It is a non-ischemic acute cardiac dysfunction that can significantly increase the mortality rate of sepsis patients, and β1-receptor blockers have anti-stress, anti-oxidation, immune regulation and cell death inhibition effects, and have potential protective effects on myocardia. This paper reviews the research progress in the effect of β1-receptor blockers on prevention and treatment of SIC. |
| Key words: Sepsis Sepsis-induced cardiomyopathy(SIC) β1-receptor blocker Esmolol Pharmacological effect |
