引用本文:胡盛惠,姚立影,魏 薇,高 岩.β1受体阻滞剂防治脓毒症心肌病作用的研究进展[J].中国临床新医学,2024,17(2):227-232.
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β1受体阻滞剂防治脓毒症心肌病作用的研究进展
胡盛惠1,姚立影1,魏 薇2,高 岩2
1.哈尔滨医科大学附属第四医院研究生院,黑龙江 150001;2.哈尔滨医科大学附属第四医院重症医学科,黑龙江 150001
摘要:
[摘要] 脓毒症心肌病是脓毒症引起的可逆性心肌损伤,是一种非缺血性急性心功能障碍,可显著增加脓毒症患者的病死率。β1受体阻滞剂具有抗应激、抗氧化、调节免疫和抑制细胞死亡及保护心肌的作用。该文对β1受体阻滞剂防治脓毒症心肌病作用的研究进展作一综述。
关键词:  脓毒症  脓毒症心肌病  β1受体阻滞剂  艾司洛尔  药理作用
DOI:10.3969/j.issn.1674-3806.2024.02.20
分类号:R 453.9
基金项目:吴阶平医学基金会临床科研专项课题(编号:32067502021084)
Research progress in the effect of β1-receptor blockers on prevention and treatment of sepsis-induced cardiomyopathy
HU Shenghui1, YAO Liying1, WEI Wei2, GAO Yan2
1.Graduate School, the Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang 150001, China; 2.Department of Critical Care Medicine, the Fourth Affiliated Hospital of Harbin Medical University, Heilongjiang 150001, China
Abstract:
[Abstract] Sepsis-induced cardiomyopathy(SIC) is a reversible myocardial injury caused by sepsis. It is a non-ischemic acute cardiac dysfunction that can significantly increase the mortality rate of sepsis patients, and β1-receptor blockers have anti-stress, anti-oxidation, immune regulation and cell death inhibition effects, and have potential protective effects on myocardia. This paper reviews the research progress in the effect of β1-receptor blockers on prevention and treatment of SIC.
Key words:  Sepsis  Sepsis-induced cardiomyopathy(SIC)  β1-receptor blocker  Esmolol  Pharmacological effect