| 摘要: |
| 探究抗生素联合牙周基础治疗（IPT）改善中重度慢性牙周炎（CP）合并2型糖尿病（T2DM）的疗效及对牙周指数和糖代谢的影响。方法 选取我院2015年1月～2016年12月治疗的64例中重度慢性牙周炎合并2型糖尿病患者进行观察，随机分为观察组和对照组，每组各32例。观察组患者予以抗生素（口服甲硝唑片+阿莫西林胶囊）联合IPT治疗方案，对照组则仅实施IPT。比较治疗前及治疗后1个月时两组患者牙周指数[牙周袋探深度（PD）、菌斑指数（PLI）、龈沟出血指数（SBI）]、糖代谢[空腹血糖（FPG）、糖化血红蛋白（HbA1c）]、炎性因子[超敏C-反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）]水平变化。结果 治疗后1个月时，两组患者各牙周指数（PD、PLI、SBI）、糖代谢指标（FPG、HbA1c）、炎症因子（hs-CRP、TNF-α）水平相比治疗前明显下降；组间比较，观察组明显低于对照组（P＜0.05）。结论 抗生素联合IPT可显著降低中重度CP合并T2DM患者牙周指数，有效改善糖代谢，对疾病转归有利。 |
| 关键词: 抗生素 牙周基础治疗 慢性牙周炎 2型糖尿病 糖代谢 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Effect of Antibiotics Combined with Periodontal Basic Treatment to Improve Moderate and Severe Periodontitis with T2DM and Its Effect on Periodontal Index and Sugar Metabolism |
|
苏佳楠1,2,3
|
|
1.Zhengzhou People'2.'3.s Hospital
|
| Abstract: |
| To investigate the efficacy of antibiotics combined with periodontal basic therapy(IPT) in improving moderate and severe periodontitis(CP) combined with type 2 diabetes mellitus(T2DM) and its effects on periodontal index and glucose metabolism. Methods 64 cases of moderate and severe periodontitis combined with type 2 diabetes mellitus treated in our hospital from January 2015 to December 2016 were observed and randomly divided into 32 cases in each group. The patients in the observation group were given antibiotics(oral metronidazole + amoxilin capsule) combined with IPT treatment, while the control group only performed IPT. Compare the periodontal index of two groups of patients before and 1 month after treatment[ Periodontal bag depth(PD), plaque index(PLI), gingival bleeding index(SBI)] , sugar metabolism[ FPG, HbA1c] , inflammatory factor[ Ultra-sensitive C-reactive protein(hs-CRP), tumor necrosis factor-α(TNF-α)] Horizontal change. Results 1 month after treatment, the levels of periodontal index(PD, PLI, SBI), glucose metabolism index(FPG, HbA1c), inflammation factor(hs-CRP, TNF-α) were significantly lower than before treatment. The observation group was significantly lower than the control group(P 0.05). Conclusion Antibiotics combined with IPT can significantly reduce the periodontal index in patients with moderate or severe CP combined with T2DM, and effectively improve sugar metabolism, which is beneficial to the disease. |
| Key words: Antibiotics Basic periodontal treatment Chronic periodontitis Type 2 diabetes Sugar metabolism |
