| 引用本文: | 朱州,黄顺荣,钟晓刚,牙韩清,李雷,王晓通.腹腔镜微创治疗老年右半结肠癌的疗效及对术后炎症状态和免疫功能的影响[J].中国临床新医学,0,():-. |
| zhuzhou.腹腔镜微创治疗老年右半结肠癌的疗效及对术后炎症状态和免疫功能的影响[J].中国临床新医学,0,():-. |
|
| 摘要: |
| 目的 对比腹腔镜手术和开腹手术治疗老年右半结肠癌的疗效以及对患者术后炎症状态和免疫功能的影响。方法 回顾性分析2017年1月至2018年6月本院收治的75例老年右半结肠癌患者,根据术式不同分为开腹手术组和腹腔镜组,其中腹腔镜组36例,开腹手术组39例。对比两组患者手术效果、术后炎症状态和T细胞亚群的变化。结果 比较两组患者手术时间、手术切口长度以及术中出血量等指标,腹腔镜组明显低于开腹手术组,差异具有统计学意义(P＜0.05)。对比两组患者血清反应蛋白(CRP)、白介素(IL-6)以及肿瘤坏死因子(TNF-α)水平,腹腔镜组明显低于开腹手术组,差异具有统计学意义(P<0.05)。术后一天,两组患者CD3<sup>+</sup>、CD4<sup>+</sup>及CD4<sup>+</sup>/CD8<sup>+</sup>水平均明显下降,且腹腔镜组下降幅度明显低于开腹手术组,术后CD8<sup>+</sup>水平明显升高,且腹腔镜组升高幅度明显低于开腹手术组,差异具有统计学意义(P<0.05)。 结论 腹腔镜手术治疗右半结肠癌近期疗效更好好、患者术后炎症反应轻、对免疫功能影响较低,值得临床推广应用。 |
| 关键词: 腹腔镜 结肠癌 开腹手术 炎症反应 免疫功能 |
| DOI： |
| 分类号: |
| 基金项目: |
|
| Influence of different operation methods in treatment of right-half colon cancer on patient’s inflammatory state and immune indexes |
|
zhuzhou
|
|
The People’s Hospital of Guangxi Zhuang Autonomous Region
|
| Abstract: |
| Objective To compare the influence of laparoscopic precise operation and laparotomy for the treatment of right-half colon cancer on patient’s operation condition, inflammatory state and immune indexes. Methods The clinical data of 75 patients with right-half colon cancer admitted to our hospital from January 2017 to June 2018 were analyzed retrospectively. All the patients were assigned to laparoscopic precise operation group (36 cases) and laparotomy group (39 cases). They were underwent laparoscopic precise operation and laparotomy operation respectively. The operation condition, inflammatory state and immune indexes were compared between the two groups. Results In laparoscopic precise operation group compared with laparotomy group, the operation time, length of incision and the amount of blood loss were all reduced (P<0.05). The CRP, IL-6 and TNF- α level in the laparoscopic precise operation group was significantly lower than that in the laparotomy group. A P value of <0.05 was considered as significant difference. At postoperative day 1, the values of CD3<sub><sup>+</sup></sub>, CD4<sub><sup>+</sup></sub> and CD4<sub><sup>+</sup></sub>/CD8<sub><sup>+</sup></sub> were significantly decreased in both groups compared with their preoperative levels, but the decreasing degrees of them in laparoscopic precise operation group were significantly less than those in laparotomy group (P<0.05), and the CD8<sub><sup>+</sup></sub> values were significantly increased in both groups compared with their preoperative levels, but the increasing degrees of them in laparoscopic precise operation group were significantly less than those in laparotomy group (P<0.05). Conclusion Laparoscopic precise operation compared with laparotomy operation for right-half colon cancer has good operation condition, less influence of inflammatory state, immune indexes, being worthy of clinical application. |
| Key words: laparoscopy colon cancer laparotomy inflammatory response immune function |
