引用本文: | 杨萌萌,陈红跃,武红园.miRNA221/222与肿瘤的研究进展[J].中国临床新医学,0,():-. |
| YANG Mengmeng,CHEN Hongyue,WU Hongyuan..miRNA221/222与肿瘤的研究进展[J].中国临床新医学,0,():-. |
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摘要: |
miRNA-221/222是一类与肿瘤发生密切相关的微小RNA,异常表达存在于机体多系统、多步骤、多位点肿瘤的分化发展进程中。miRNA-221/222通过靶向不同靶基因的信号传导途径发挥着抑癌基因或促癌基因的作用,有望成为恶性肿瘤的生物学标志物和新型治疗靶点。 |
关键词: miRNA-221/222、肿瘤、靶基因 |
DOI: |
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基金项目:河南省中医药科学研究专项课题(2016ZY2063) |
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Advances in researchs of miRNA-221/222 and carcinoma |
YANG Mengmeng,CHEN Hongyue,WU Hongyuan.
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Henan University of Chinese Medicine
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Abstract: |
MiRNA-221/222 is a kind of microRNA closely related to tumorigenesis, which is abnormally expressed in the differentiation and development process of multi-system, multi-step and multi-site tumors. miRNA-221/222 plays a role as a tumor suppressor gene or a tumor-promoting gene through signaling pathways targeting different target genes, and is expected to become a biomarker and a novel therapeutic target for malignant tumors. |
Key words: MiRNA-221/222 Tumor Target gene |