| 引用本文: | 莫祥兰,殷舞,黄永塔,郭文文,温宗华,陈慧玲.广西地区鼻NK/T细胞淋巴瘤p-ATM和CHK2表达及其临床意义[J].中国临床新医学,0,():-. |
| Mo Xianglan,Yin Wu,Huang Yongta,Guo Wenwen,Wen Zonghua,Chen Huiling.广西地区鼻NK/T细胞淋巴瘤p-ATM和CHK2表达及其临床意义[J].中国临床新医学,0,():-. |
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| 摘要: |
| 目的 研究广西地区鼻NK/T细胞淋巴瘤（NKTCL）组织p-ATM和CHK2蛋白表达及其临床意义。方法 收集 2010-01～2016-12该院49例鼻NKTCL组织及其来源患者的临床资料，另取30例同期鼻咽粘膜良性淋巴组织增生（NBLP）组织作为对照组。比较p-ATM蛋白和CHK2蛋白在鼻NKTCL组织和NBLP组织间的表达差异。分析NKTCL组织p-ATM蛋白和CHK2蛋白表达水平与患者临床特征及预后的关联。结果 鼻NKTCL组高表达p-ATM蛋白者23例（46.94%），高表达CHK2蛋白者24例（48.98%），NBLP组无高表达p-ATM蛋白和CHK2蛋白者，两组比较差异有统计学意义（p＜0.05）。鼻NKTCL组织CHK2高表达组临床分期为I/II期的比例显著低于CHK2低表达组（p＜0.05）。Kaplan-Meier 分析结果显示，鼻NKTCL组织p-ATM高表达组的中位生存时间为6个月，p-ATM低表达组中位生存时间为21个月，低表达组生存预后优于高表达组（P=0.011）；鼻NKTCL组织CHK2高表达组的中位生存时间为7个月，低表达组中位生存时间为21个月，低表达组生存预后优于高表达组（P=0.025）。鼻NKTCL组织p-ATM蛋白和CHK2蛋白表达呈显著正相关（p＜0.05）。结论 ATM/CHK2通路异常在广西地区鼻NKTCL的发生和发展中具有重要作用。检测鼻NKTCL组织p-ATM和CHK2蛋白表达水平有助于评估患者预后。 |
| 关键词: 鼻NK/T细胞淋巴瘤，p-ATM，CHK2，预后 |
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| 基金项目:国家自然科学基金(编号：81360355)；广西自然科学基金(编号：2017GXNSFAA198055)；广西卫健委自筹经费科研课题(编号：Z20170307) |
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| The clinical significance of p-ATM and CHK2 expression in nasal nature killer/T cell lymphoma of Guangxi |
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Mo Xianglan, Yin Wu, Huang Yongta, Guo Wenwen, Wen Zonghua, Chen Huiling
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Department of Pathology,People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning,Guangx,530021.
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| Abstract: |
| Objective To study the expression and their clinical significance of p-ATM and CHK2 proteins in nasal nature killer/T cell lymphoma (NKTCL) tissues of Guangxi. Methods The clinical data and tumor tissues of 49 cases of nasal NKTCLs in Guangxi between 2010-01 and 2016-12 were collected. Thirty cases of nasopharygeal mucosa benign lymphoid proliferation (NBLP) were taken as control group. The differential-expression of p-ATM and CHK2 between NKTCL and NBLP groups were analyzed. The correlation among the expression of the proteins and the clinicopathological features as well as prognosis of the patients with nasal NKTCL were also evaluated.
Results High-level expression of p-ATM and CHK2 proteins were detected in 23 cases（46.94%）and 24 cases（48.98%）of nasal NKTCLs,respectively. None of the NBLP group was high-level expression of p-ATM and CHK2. The expression of p-ATM and CHK2 were significantly increased in the nasal NKTCL group compared with the NBLP group (p＜0.05）. In nasal NKTCLs, the ratio of the patients with clinical stage I/II were significantly decreased in the group of high-CHK2 expression compared with the low-CHK2 expression group（p＜0.05）.Kaplan-Meier analyzed showed the medium survival of the patients with high-level expression of p-ATM was 6 months，while the medium survival of the patients with low-expression of p-ATM was 21 months. The survival time of the nasal NKTCLs with low-expression of p-ATM was longer than those with high-expression of p-ATM（P=0.011）. The medium survival of the patients with high-level expression of CHK2 was 7 months，while the medium survival of the patients with low-expression of CHK2 was 21 months. The survival time of the patients with low-level expression of CHK2 was longer than those with high-level expression of CHK2（P=0.025）.There was a positive correlation between the expression of p-ATM and CHK2 in the nasal NKTCL tissues（p＜0.05）.
Conclusions Abnomality of the ATM/CHK2 signal pathway may contribute to the oncogenesis and development of nasal NKTCL in Guangxi. Detect the expression of p-ATM and CHK2 may help to predict the prognosis of the patent with nasal NKTCL in Guangxi. |
| Key words: nasal nature killer/T cell lymphoma p-ATM CHK2 prognosis |
