| 摘要: |
| 目的 探讨枸橼酸氢钾钠对经皮肾镜取石术后临床无意义残留结石发展的干预作用。方法 将60例因上尿路结石并行经皮肾镜取石术(Percutaneous ephrolithotomy,PCNL)术后确诊临床无意义残留结石(clinically insignificant residual fragments,CIRF)的患者纳入研究,随机分成对照组(n=29)和干预组(n=31)。干预组患者在术后给予枸橼酸氢钾钠颗粒10g/d,共3个月。比较两组术后临床症状的发生率以及结石的消失或生长情况变化。结果术后12个月干预组与对照组残石增大发生率分别为12.9%(4/31)与62.1%(18/29)、残石消失发生率分别为41.9%(13/31)与17.2%(5/29)、残石减少或不变的发生率分别为45.2%(14/31)与20.7%(6/29)、差异均有统计学意义(P<0．05)。术后残石相关肾绞痛的发生率分别为7.1%(2/31)与28.1%(9/29),差异有统计学意义(P<0．05)；血尿的发生率分别为25.8%(8/31) 与51.7%(15/29) ,差异无统计学意义(P<0．05)。结论 枸橼酸氢钾钠对经皮肾镜取石术后临床无意义残留结石患者的结石发展起到明显的干预作用,抑制CIRF生长,促进CIRF排出,减少CIRF引发的肾绞痛。 |
| 关键词: 枸橼酸氢钾钠 经皮肾镜取石术 临床无意义残留结石 |
| DOI： |
| 分类号: |
| 基金项目:广西医疗卫生重点科研课题 (桂卫重2012104) |
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| Effect of potassium sodium hydrogen citrate on CIRF after Percutaneous Nephrolithotomy |
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韦秀望
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People‘s Hospital of Guangxi Zhuang Autonomous Region
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| Abstract: |
| Objective To discuss the intervention effect of potassium sodium hydrogen citrate on clinically insignificant residual fragments(CIRF) after percutaneous nephrolithotomy(PCNL).Methods 60 patients of renal calculi after PCNL with CIRF were enrolled in this study. All the patients were Randomly divided into control group and intervention group.The intervention group were given oral potassium sodium hydrogen citrate granules 10g per day, another subgroup given no treantment were selected as the control group.The stone condition were compared between the two subgroups after 12 months follow-up. Results The growth rate of CIRF in intervention group and control group respectively are 12.9%(4/31) and 62.1%(18/29).The incidence of residual stone disappeared are 41.9%(13/31) and 17.2%(5/29).The incidence of residual stone to reduce or unchanged are 45.2%(14/31) and 20.7%(6/29).The residual stone related renal colic are 7.1%(2/31) and 28.1%(9/29).The difference had statistical significance(P<0．05). The incidence of blood in the urine are 25.8%(8/31) and 51.7%(15/29), The difference had no statistical significance(P<0．05). Conclusion Potassium sodium hydrogen citrate therapy can intervene the development of CIRF after PCNL:Inhibit the growth of CIRF,promote the discharge of CIRF and reduce CIRF caused renal colic. |
| Key words: potassiumsodiumhydrogencitrate percutaneousnephrolithotomy clinically insignificant residual fragments |
