| 摘要: |
| 摘要： 目的：探讨有创机械通气联合布地奈德振动筛孔雾化吸入对婴幼儿重症肺炎的影响。方法：选取180例婴幼儿重症肺炎行有创机械通气的患儿，随机分为对照组和干预组各90例。两组均给予常规治疗，其中对照组给予雾化吸入3ml 0.9％氯化钠溶液，2次/d；干预组给予布地奈德1ml溶于生理盐水2ml中，应用振动筛孔给予雾化吸入，2次/d。两组均持续治疗7d。比较两组患儿治疗后痰液黏稠度、血氧饱和度、血气指标、雾化过程中呼吸机监测指标、机械通气时间和儿童重症监护病房(PICU)住院时间的变化情况。结果：治疗7d后干预组痰液黏稠度改善情况优于对照组，氧分压、血氧饱和度显著高于对照组，二氧化碳分压显著低于对照组，比较差异均具有统计学意义，均P<0.05；干预组机械通气时间、PICU住院时间均短于对照组，均P<0. 05；与本组雾化前比较，使用振动网筛雾化器进行雾化对机械通气患儿影响小，雾化前与雾化中潮气量、呼吸频率、气道峰压比较差异无统计学意义，均P>0.05。结论：有创机械通气联合布地奈德振动筛孔雾化吸入对婴幼儿重症肺炎效果较显著，可有效改善患儿的痰液黏稠度，减轻炎性反应，缩短患儿机械通气及PICU住院时间，且振动网筛雾化器对通气影响小，安全性高，适用于机械通气的婴幼儿进行雾化吸入。 |
| 关键词: 布地奈德 有创机械通气 振动筛孔雾化 重症肺炎 婴幼儿 |
| DOI： |
| 分类号: |
| 基金项目:广西壮族自治区卫生健康委员会自筹经费科研课题 |
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| Observation on the effect of invasive mechanical ventilation combined with budesonide vibrating sieve atomization inhalation in the treatment of infant with severe pneumonia |
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qingkunli
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Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
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| Abstract: |
| [Abstract]Objective: To investigate the effect of invasive mechanical ventilation combined with budesonide vibrating sieve atomization inhalation on infants and young children with severe pneumonia. Methods: A total of 180 infants with severe pneumonia were randomly divided into control group and intervention group, 90 cases in each group. Both groups were given conventional treatment, in which, the control group was given atomization inhalation of 3ml-0.9% sodium chloride solution,twice a day;the intervention group was given budesonide 1ml dissolved in 2ml normal saline, using vibrating sieve, twice a day. Both groups continued treatment for 7 days. The changes in sputum viscosity, blood oxygen saturation, blood gas indicators, ventilator monitoring indicators during atomization, mechanical ventilation time and hospitalization time in children's intensive care unit (PICU) were compared between the two groups. Results: after 7 days of treatment, the improvement of sputum viscosity in the intervention group was better than that of the control group. The oxygen partial pressure and blood oxygen saturation were significantly higher than those of the control group, and the carbon dioxide partial pressure was significantly lower than that of the control group. The differences were statistically significant, both P<0.05; The mechanical ventilation time and PICU hospitalization time in the intervention group were shorter than those in the control group, both P<0.05; Compared with this group before atomization, the effect of vibrating sieve atomizer on children with mechanical ventilation was less. There was no significant difference in tidal volume, respiratory frequency and airway peak pressure before and during atomization (P > 0.05). Conclusion: the effect of invasive mechanical ventilation combined with budesonide vibrating sieve atomization inhalation on infants with severe pneumonia is significant, which can effectively improve the sputum viscosity, reduce the inflammatory reaction, and shorten the duration of mechanical ventilation and PICU in children.
[Key words] Budesonide；Invasive mechanical ventilation; Puerpera；Shaker hole atomization；Infants and young children. |
| Key words: Budesonide Invasive mechanical ventilation Puerpera Shaker hole atomization Infants and young children. |
