| 摘要: |
| 妊娠期糖尿病（GDM）是妊娠常见并发症之一，表现为妊娠期糖代谢异常，对母儿造成严重的影响。妊娠期肠道菌群数量和种类出现生理性改变，大量研究表明，肠道菌群多样性及丰富度的改变是造成妊娠期糖尿病发生发展的潜在因素。本文通过既往对妊娠期糖尿病女性菌群改变的研究文献进行综述，主要论及GDM潜在的发病机制及GDM防治思路。 |
| 关键词: 妊娠期糖尿病 肠道菌群 内毒素 胰岛素抵抗 短链脂肪酸 |
| DOI： |
| 分类号: |
| 基金项目:深圳市自然科学基金项目（JCYJ20190807144403563） |
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| Research progress on gestational diabetes mellitus and intestinal microflora changes |
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caoyuzhi
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2nd Clinical Medical College of Jinan University
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| Abstract: |
| Gestational diabetes mellitus (GDM) is one of the common complications of pregnancy, which manifests as abnormal glucose metabolism during pregnancy and causes serious effects on mother and child. Physiological changes in the number and type of intestinal flora occur during pregnancy, and numerous studies have shown that changes in the diversity and abundance of intestinal flora are potential contributors to the development of gestational diabetes. In this paper, we review the literature on the altered flora of women with gestational diabetes mellitus, focusing on the potential pathogenesis of GDM and ideas for the prevention and treatment of GDM. |
| Key words: Gestational diabetes mellitus,Intestinal flora,endotoxin,Insulin resistance,Short chain fatty acid |
