| 摘要: |
| ［摘要］ 目的 分析三大唾液腺（腮腺、颌下腺和舌下腺）肿瘤的临床病理特征，为该疾病的诊断和治疗提供参考。方法 回顾性分析2000年1月至2020年12月中国人民解放军南部战区总医院收治的656例腮腺、颌下腺和舌下腺肿瘤患者的临床病理资料。参考世界卫生组织（WHO）对唾液腺肿瘤的组织病理学分类及分型标准进行分类和统计，总结三大唾液腺肿瘤的临床病理特征。结果 本组656例患者中男性411例（62.65%），女性245例（37.35%）；发病年龄以35～64岁为主（52.90%）。良性肿瘤465例（70.88%），恶性肿瘤191例（29.12%）。发生于腮腺者545例（83.08%），颌下腺者97例（14.79%），舌下腺者14例（2.13%）。在良性肿瘤中占比居前3位分别是多形性腺瘤（46.88%，218/465）、腺淋巴瘤（33.33%，155/465）和基底细胞腺瘤（5.59%，26/465），其中多形性腺瘤在所有肿瘤中占33.23%（218/656）。191例恶性肿瘤中，发生于腮腺143例（74.87%），颌下腺34例（17.80%），舌下腺14例（7.33%）。在恶性肿瘤中占比居前3位的分别是腺样囊性癌（25.65%，49/191）、黏液表皮样癌（18.85%，36/191）和腺泡细胞癌（13.09%，25/191）。结论 三大唾液腺肿瘤患者中男性占比高于女性，多发于35～64岁人群，发病部位主要为腮腺。在良性肿瘤中以多形性腺瘤占比最高，在恶性肿瘤中以腺样囊性癌占比最高。 |
| 关键词: 唾液腺肿瘤 病理学特征 临床特征 |
| DOI：10.3969/j.issn.1674-3806.2026.03.10 |
| 分类号:R 739.87 |
| 基金项目:广东省基础与应用基础研究基金项目（编号：2024A1515220159）；广东省医学科学技术研究基金项目（编号：B2024207） |
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| Clinicopathological features of tumors of the three major salivary glands: an analysis of 656 cases |
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JIAN Lan1, OUYANG Qinghua1, HU Jingran1, LUO Yirong1, SUN Shuohui1, WANG Zhifa1,2
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1.Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China; 2. School of Stomatology, Southern Medical University, Guangzhou 510510, China
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| Abstract: |
| ［Abstract］ Objective To analyze the clinicopathological features of tumors of the three major salivary glands(parotid gland, submandibular gland and sublingual gland), and to provide reference for the diagnosis and treatment of these diseases. Methods A retrospective analysis was conducted on the pathological data of 656 patients with tumors of the parotid gland, submandibular gland and sublingual gland who were admitted to General Hospital of Southern Theater Command of PLA from January 2000 to December 2020. The classification and statistics of the salivary gland tumors were carried out by referring to the histopathological classification and typing criteria of salivary gland tumors by the World Health Organization(WHO), and the clinicopathological features of the tumors of the three major salivary glands were summarized. Results Among the 656 patients, 411 patients were male(62.65%) and 245 patients were female(37.35%). The age of the patients at the time of onset was mainly distributed between 35 and 64 years(52.90%). There were 465 cases(70.88%) of benign tumors and 191 cases(29.12%) of malignant tumors. There were 545 cases(83.08%) of tumors occurring in the parotid gland, 97 cases(14.79%) of tumors occurring in the submandibular gland and 14 cases(2.13%) of tumors occurring in the sublingual gland. In the benign tumors, the top 3 tumors in terms of proportion were pleomorphic adenoma(46.88%, 218/465), Warthin tumor(33.33%, 155/465) and basal cell adenoma(5.59%, 26/465), among which pleomorphic adenoma accounted for 33.23%(218/656) of all the tumors. Among the 191 cases of malignant tumors, 143 cases(74.87%) of tumors occurred in the parotid gland, 34 cases(17.80%) of tumors in the submandibular gland and 14 cases(7.33%) of tumors in the sublingual gland. In the malignant tumors, the top 3 tumors in terms of proportion were adenoid cystic carcinoma(25.65%, 49/191), mucoepidermoid carcinoma(18.85%, 36/191) and acinic cell carcinoma(13.09%, 25/191). Conclusion Among the patients with the tumors of the three major salivary glands, the proportion of male patients is higher than that of female patients. These tumors are more common in the population aged 35 to 64 years. The tumor sites are mainly located in the parotid gland. Among the benign tumors, pleomorphic adenoma accounts for the highest proportion. Among the malignant tumors, adenoid cystic carcinoma accounts for the highest proportion. |
| Key words: Salivary gland tumors Pathological features Clinical features |
