| 摘要: |
| ［摘要］ 髌股关节炎是中老年人群常见的膝关节退行性疾病，其主要表现为膝前疼痛、上下楼梯困难等。近年来，该病的发病率呈逐年上升趋势，不仅严重影响患者的生活质量，而且还给社会带来沉重的经济负担。目前针对髌股关节炎的治疗方法较多，但个体化治疗仍处于研究的起步阶段。生物治疗作为一种新兴的治疗手段，通过促进软骨再生、调节免疫、减轻炎症反应以及分泌生物活性物质等途径发挥治疗作用，逐渐成为髌股关节炎治疗的研究热点。该文对生物治疗在髌股关节炎治疗中的研究进展作一综述。 |
| 关键词: 膝关节骨关节炎 髌股关节炎 生物治疗 间充质干细胞 脐带血单个核细胞 |
| DOI：10.3969/j.issn.1674-3806.2026.03.21 |
| 分类号: |
| 基金项目:山东省医学会脐带血临床科研专项资金项目（编号：YXH2021ZX063） |
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| Research progress of biological therapy in treatment of patellofemoral osteoarthritis |
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JIA Shuwei1, XU Qi2, HUO Lukuan1, WU Xiaozhe1, HA Chengzhi2
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1.School of Clinical Medicine,Shandong Second Medical University, Weifang 261053, China; 2.Beijing Jishuitan Hospital, Liaocheng Hospital, Liaocheng 252000, China
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| Abstract: |
| ［Abstract］ Patellofemoral osteoarthritis is a common degenerative disease of the knee joints among middle-aged and elderly populations. The main manifestations of patellofemoral osteoarthritis include anterior knee pain and difficulty in going up and down stairs. In recent years, the incidence of the disease has been on the rise year by year, which not only seriously affects the quality of life of the patients but also imposes a significant economic burden on society. At present, there are many treatment methods for patellofemoral osteoarthritis, but individualized treatments are still in the early stages of the research. Biological therapy, as an emerging therapeutic approach, exerts therapeutic effects through promoting cartilage regeneration, regulating immunity, reducing inflammatory responses and secreting bioactive substances, and gradually becomes a research hotspot in the treatment of patellofemoral osteoarthritis. In this paper, the research progress of biological therapy in treatment of patellofemoral osteoarthritis is reviewed. |
| Key words: Knee osteoarthritis Patellofemoral osteoarthritis Biological therapy Mesenchymal stem cells Umbilical cord blood mononuclear cells |
