| 摘要: |
| ［摘要］ EB病毒（EBV）是一种普遍存在的致瘤性疱疹病毒，与多种疾病密切相关，包括传染性单核细胞增多症、慢性活动性EBV感染及EBV相关自身免疫疾病等，其主要感染人群为3～5岁的儿童。近年来的研究发现，辅助性T细胞17（Th17）和调节性T细胞（Treg）的免疫失衡在EBV感染相关疾病的发生发展中起着重要作用。EBV可通过调控宿主免疫应答，破坏Th17/Treg平衡，进而引发免疫系统紊乱，为病毒的长期感染和相关疾病的进展提供了有利条件。该文对儿童EB病毒感染相关疾病Th17/Treg免疫失衡的研究进展作一综述。 |
| 关键词: 儿童 EB病毒 辅助性T细胞17 调节性T细胞 Th17/Treg平衡 |
| DOI：10.3969/j.issn.1674-3806.2026.06.22 |
| 分类号: |
| 基金项目:常州市科技计划项目（编号：CJ20245010） |
|
| Research progress of the immunological imbalance of Th17/Treg in children with Epstein-Barr virus infection-related diseases |
|
YANG Pengli, PANG Gaofeng
|
|
Department of Pediatrics and Neonatology, the Third Affiliated Hospital of Soochow University(the First People′s Hospital of Changzhou), Changzhou 213003, China
|
| Abstract: |
| ［Abstract］ Epstein-Barr virus(EBV) is a type of ubiquitous oncogenic herpes virus and closely associated with various diseases such as infectious mononucleosis, chronic active EBV infection, and EBV-related autoimmune disorders. EBV primarily infects children aged 3 to 5 years. Recent studies reveals that the immunological imbalance of Th17(T helper cells 17)/Treg(regulatory T cells) plays a significant role in the development and progression of EBV-associated diseases. EBV can disrupt the balance of Th17/Treg by regulating host immune responses, leading to immune system disorders and creating favorable conditions for persistent viral infection and progression of related diseases. In this paper, the research progress of the immunological imbalance of Th17/Treg in children with EBV infection-related diseases is reviewed. |
| Key words: Children Epstein-Barr virus(EBV) T helper cells 17(Th17) Regulatory T cells(Treg) Balance of Th17/Treg |
