| 摘要: |
| ［摘要］ 目的 探讨墓头回提取液对小鼠宫颈癌U14移植瘤瘤体组织微血管密度、VEGF、bFGF表达的影响。方法 将SPF级雌性KM小鼠随机分成墓头回提取液高、中、低剂量组、顺铂组及模型组，以观察墓头回提取液对U14实体瘤肿瘤组织微血管密度、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子（bFGF）表达的影响。结果 墓头回提取液高、中剂量组和顺铂组的宫颈癌U14移植瘤瘤体内微血管密度均明显低于模型组；墓头回提取液高、中剂量组和顺铂组均可降低U14移植瘤瘤体内VEGF的表达；墓头回提取液高剂量组和顺铂组均可降低U14移植瘤瘤体内bFGF的表达。结论 墓头回提取液能明显抑制U14移植瘤瘤体血管形成，并能降低VEGF、bFGF的表达，提示墓头回提取液有抗肿瘤作用。 |
| 关键词: 墓头回提取液 小鼠宫颈癌U14 微血管密度 VEGF bFGF |
| DOI： |
| 分类号:R 737.33 |
| 基金项目:2007年广西自然科学基金资助项目（№：桂科自0728183）及2007年广西壮族自治区大型仪器协作共用网资助项目 |
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| Effect of the extracting solution from mutouhui on the microvessel-density and VEGF/bFGF expression in the U14 replanted tumor tissues of the mice that had cervical carcinoma |
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JIANG Qiu-yan, FANG Gang, SU Li-ming, et al.
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First Teaching Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530023, China
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| Abstract: |
| ［Abstract］ Objective To explore the effect of the extracting solution from mutouhui on the microvessel-density and VEGF/bFGF expression in the U14 replanted tumor tissues of the mice that had cervical carcinoma.Methods The SPF female mice were divided into high dose/ middle dose/ light dose of the extracting solution group, cisplatin group and model group randomly.Then the effect of the extracting solution from mutouhui on the microvessel-density and VEGF/bFGF expression in the U14 replanted tumor tissues of the mice that had cervical carcinoma were observed.Results The microvessel-density in high dose/ middle dose of extracting solution group and cisplatin group was lower than that in model group; VEGF expression in high dose/ middle dose of extracting solution group and cisplatin group was lower than that in model group; bFGF expression in high dose/ middle dose of extracting solution group and cisplatin group was lower than that in model group. Conclusion The extracting solution from mutouhui is against the formation of the microvessel-density in U14 transplanted tumor, and it also can reduce the VEGF/bFGF expression, all these show that extracting solution from mutouhui has the effect of anti-tumor. |
| Key words: Extracting solution from Mutouhui Mice of U14 cervical carcinoma Microvessel density VEGF bFGF |
