| 摘要: |
| ［摘要］ 目的 调查南宁市区乙型肝炎病毒(HBV)阳性孕妇的新生儿HBV感染情况。方法 将511例乙肝表面抗原(HBsAg)阳性的孕妇按HBsAg、HBeAg、抗-HBc三项指标阳性者分为“大三阳”组，共191例，HBsAg、抗-HBe、抗-HBc三项指标阳性者为“小三阳”组，共320例，并对其所生的新生儿在出生后24 h内进行乙肝两对半的检测。结果 “大三阳”组孕妇的新生儿HBV感染92例，感染率48.17%；“小三阳”组孕妇的新生儿HBV感染12例，感染率3.75%；两组比较χ2=145.575，P<0.01，差异有统计学意义。结论 孕妇乙肝“大三阳”是新生儿发生HBV感染的高危因素，应加强HBV阳性孕妇的宫内阻断，减少新生儿发生HBV感染。 |
| 关键词: HBV感染 孕妇 新生儿 |
| DOI：10.3969/j.issn.1674-3806.2009.07.31 |
| 分类号:R 512.6 |
| 基金项目: |
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| Investigation on the condition of the neonatal HBV infection in 511 HBV-positive pregnant women in Nanning |
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GAN Zhi-yuan
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Depastment of Laboratory, Nanning City MCH Hospital, Nanning 530011, China
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| Abstract: |
| ［Abstract］ Objective To investigate the condition of the neonatal HBV infection in hepatitis B virus (HBV)-positive pregnant women.Methods Among 511 hepatitis B surface antigen (HBsAg)-positive pregnant women, 191 women with HBsAg, HBeAg, anti-HBc positive were divided into “great three positive” group, 320 women with HBsAg, anti-HBe, anti-HBc positive were divided into “small three positive” group. And their newborns born within 24 h after birth were tested out five indicators of hepatitis B.Results In “great three positive” group 92 neonates were infected by HBV, the infection rate was 48.17%; In “small three positive” group 12 neonates were infected by HBV, the infection rate was 3.75%; The difference between two groups had statistical significance P<0.01. Conclusion The “great three positive” in pregnant women are risk factors of neonatal HBV infection, It should be necessary to strengthen the blocking of the HBV intrauterine infection of HBV-positive pregnant women, In order to reduce the occurrence of HBV infection in newborns. |
| Key words: HBV infection Pregnant women Newborns |
