| 摘要: |
| ［摘要］ 目的 观察硝苯地平缓释片联合依那普利的降压作用、不良反应及对代谢的影响。方法 将96例原发性高血压病患者随机分为治疗组和对照组各48例，治疗组服用硝苯地平缓释片及依那普利，对照组单纯服用依那普利，疗程4周，由固定医生测坐位血压，于治疗前后测血糖、血脂、电解质、肝功能、肾功能，并行心电图检查。结果 治疗组和对照组在服药4周后显效率分别为45.8%、25.0%，总有效率分别为95.8%、68.7%，两组比较差异有统计学意义（P<0.05或P<0.01），而两组治疗对糖代谢、脂代谢、电解质、肝功能、肾功能及心电图并无明显影响。结论 硝苯地平联合依那普利降压效果好，副作用小，值得临床推广应用。 |
| 关键词: 高血压病 硝苯地平缓释片 依那普利 联合用药 |
| DOI：10.3969/j.issn.1674-3806.2009.09.17 |
| 分类号:R 544.1 |
| 基金项目: |
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| Curative observation of nifedipine sustained-release tablet combined with enalapril in the treatment of 48 patients with hypertension |
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HUANG Shang-neng
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Department of Cardioiogy, Tiandong People′s Hospital, Tiandong, Guangxi 531500, China
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| Abstract: |
| ［Abstract］ Objective To observe the decompression effect， adverse reaction and metabolism effect of nifedipine sustained-release tablet combined with enalapril.Methods Ninety-six patients with hypertension were randomly divided into treatment group and control group，in which there′s 48 patients respectively, the patients in treatment group were treated with nifedipine sustained-release tablet combined with enalapril, and only enalapril were given in control group, this course of treatment was 4 weeks, their blood presure were measured by the same doctor from beginning to end, and the blood sugar, blood-lipid, electrolyte, hepatic function and renal function before and after treatment were determined, and also did electrocardiogram.Results After treatment for four weeks，the effectiveness rate of treatment group and control group were 45.8 percent and 25.0 percent respectively， and the total effective rate were 95.8 percent and 68.7 percent respectively. There were significant difference between the two groups(P<0.05 or P<0.01), and no effects on glycometabolism, lipid metabolism, electrolyte, hepatic function, renal function and electrocardiogram of the two groups.Conclusion There is very good effects of nifedipine sustained-release tablet combined with enalapril on the decompression, with less side effect，it is well worth widely using in clinic. |
| Key words: Hypertension Nifedipine sustained-release tablet Enalapril Combined drugs |
