| 摘要: |
| ［摘要］ 目的 了解急性肾功能衰竭（ARF）的病因构成、预后以及影响ARF病死率的危险因素等临床流行病学特征，为急性肾功能衰竭的早期防治提供理论依据。方法 对广西医科大学第一附属医院2002-01-01～2006-12-31在各科住院的ARF患者的临床资料进行回顾性分析，并研究其病因、临床特征及其转归。结果 观察期间共有住院患者193 038例次, 其中611例患者发生ARF, 占同期住院人数的0.32%；男女比例为1.87∶1.00，中位年龄40岁。肾前性118例（19.31%），肾前性ARF的病因首位为心排出量减低（35例, 29.66%）；肾实质性372例(60.88%)，肾小管间质病变是肾实质性ARF首位病因（236例），其中药物性95例(40.25%)；肾后性121例（19.80%），其中尿路结石84例（69.42%）。有慢性肾脏病基础ARF共201例，占总ARF的32.90%。观察期间ARF病死率14.89%，Logistic回归分析提示少尿、是否合并MODS、获得性ARF是住院病死率相关的危险因素。结论 心排出量减低、药物性肾损害、尿路结石分别是引起肾前性、肾实质性、肾后性ARF的首位病因；慢性肾脏病基础ARF并不少见。少尿、合并MODS、获得性ARF的患者病死率高。 |
| 关键词: 肾功能衰竭 急性 流行病学 病因 预后 |
| DOI：10.3969/j.issn.1674-3806.2009.11.02 |
| 分类号:R 692.5 |
| 基金项目:广西壮族自治区卫生厅科研课题项目（Z2007087） |
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| The clinical epidemiology analysis of 611 patients with acute renal failure |
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HUANG Li, XU Jin, LIAO Yun-hua
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Department of Nephrology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the etiology, prognosis, risks factors of death among acute renal failure (ARF) patients，and provide a theory basis for the prevention and treatment of ARF.Methods ARF patients admitted in First Affiliated Hospital，Guangxi Medical University from January 1st 2002 to December 31st 2006 were analyzed retrospectively, according to the etiology, clinical features, prognosis.Results There were 193 038 admissions during the study period and 611 met the diagnostic criteria of ARF.The overall incidence of ARF was 0.32%. The ratio of male：female of ARF was 1.87∶1.00 with median age 40 years o1d. Among 611 patients, 118(19.31%) were pre-renal ARF, the first cause of pre-renal ARF was low cardiac output(35 cases， 29.66%）.Three hundred and seventy-two(60.88%) patients were renal parenchymal ARF, the main cause of parenchymal ARF was tubulointerstitial injures(236 cases); of them 95 cases were caused by drugs. One hundred and twenty-one (19.80%) patients were post-renal ARF, the main cause of post-renal ARF was urinary stone disease(84/121). Two hundred and one(32.90%) patients were acute-on-chronic renal failure(A/C). The mortality was 14.89% in patient with ARF.The results of logistic regression analysis suggested the oliguria, MODS and HA-ARF were the risk factors of death among ARF patients.Conclusion Low cardiac output, drugs, urinary stone disease were the main cause of pre-renal ARF, parenchymal ARF, post-renal ARF respectively.A/C was an common part of ARF. The mortality of ARF patients with oliguria, MODS and HA-ARF was higher. |
| Key words: Renal failure Acute Epidemiology Etiology Prognosis |
