| 摘要: |
| ［摘要］ 目的 探讨福州地区多巴胺D4受体（dopamine receptor D4，DRD4）-521C→T（rs1800955）基因多态性与老年男性原发性骨质疏松的相关性。方法 应用聚合酶链反应（Polymerase chain reaction, PCR）及基因测序技术，检测分析70名老年男性骨质疏松病人及70名健康老年男性的DRD4基因型及等位基因。结果 骨质疏松病人基因型及等位基因频率分布与健康老年男性相比较，差异无统计学意义（分别是： χ2=3.79，P>0.05； χ2=3.38，P>0.05）。结论 未能证实DRD4基因为福州地区老年男性原发性骨质疏松的候选基因。 |
| 关键词: 骨质疏松 男性 DRD4 基因多态性 |
| DOI：10.3969/j.issn.1674-3806.2010.02.07 |
| 分类号:R 589 |
| 基金项目: |
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| Relationship between the polymorphism of dopamine receptor D4 and primary osteoporosis in elder men |
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ZENG Yue-gui, CHEN Yan, YAO Jin, et al.
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Provincial Clinical College of Fujian Medical University, Fuzhou 350000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the relationship between the polymorphism of dopamine receptor D4 (DRD4) and primary osteoporosis in elder men in Fuzhou.Methods In 70 aged male patients with osteoporosis and 70 healthy older men, the genotypes and alleles of DRD4 were detected and analyzed by using the polymerase chain reaction and gene sequencing techniques.Results Osteoporosis genotype and allele frequency distribution of patients compared with healthy older men was no significant difference (respectively χ2=3.79，P>0.05；χ2=3.38，P>0.05).Conclusion DRD4 gene could not be confirmed as candidate genes for primary osteoporosis in elderly men in Fuzhou region. |
| Key words: Osteoporosis Male DRD4 Genetic polymorphisms |
