| 摘要: |
| ［摘要］ 目的 观察氨茶碱联合纳络酮治疗早产儿原发性呼吸暂停的临床疗效。方法 将52例发生呼吸暂停的早产儿随机分为两组，治疗组和对照组各26例。两组均应用氨茶碱，首剂5 mg/kg,12 h后给予维持量2.5 mg/kg,q 12 h,治疗组在上述治疗基础上加用纳络酮0.1 mg/kg静脉推注，继之予0.1～0.2 mg/kg，按0.03～0.05 mg/(kg·h)速度持续静脉泵入，6～8 h/d，两种药物均用3～5 d。结果 治疗组显效19例（73.07%），有效6例（23.07%），无效1例（3.84%）；对照组显效10例（38.46%），有效8例（30.76%），无效8例（30.76%）。总有效率治疗组96.15%，对照组69.23%，两组比较差异有统计学意义（χ2=4.84,P<0.05）。结论 氨茶碱联合纳络酮治疗早产儿原发性呼吸暂停疗效显著。 |
| 关键词: 早产儿 原发性呼吸暂停 纳络酮 氨茶碱 |
| DOI：10.3969/j.issn.1674-3806.2010.08.22 |
| 分类号:R 722.6 |
| 基金项目: |
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| Clinical observation on the effect of aminophylline combined with naloxone in the treatment of the premature infants with primary apnea |
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MAO Ying,ZHANG Gang,LI Hua
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The People′s Hospital of Hezhou,Guangxi 542800,China
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| Abstract: |
| ［Abstract］ Objective To observe the efficiency of aminophylline combined with naloxone in treatment of premature infants with primary apnea.Methods Fifty-two patients were randomly divided into two groups:the treatment group and the control group, each group contained 26 cases. Aminophylline were used in both groups,the first dose was 5 mg/kg，after 12 hours，followed by 2.5 mg/kg，one time per 12 hours.The treatment group was added naloxone in an initial dose of 0.1 mg/kg intravenous injection on the basis of the control group, followed by naloxone 0.1～0.2 mg/kg, at a speed of 0.03～0.05 mg/(kg·h), 6～8 h every day, continuous intravenous infusion for 3～5 days.Results In the treatment group，marked effect was found in 19 cases（73.07%）, improvement in 6 cases (23.07%）and no effect in 1 case（3.84%）; In the control group marked effect in 10 cases (38.46%）,improvement in 8 cases（30.76%）,no effect in 8 cases （30.76%）.The total effective rate of the treatment group was 96.15%, that of the control group was 69.23%.The difference of the total effective rates between two groups was significant (χ2=4.84，P<0.05).Conclusion Aminophylline plus naloxone in treatment of premature infant with primary apnea is effective. |
| Key words: Premarure infants Primary apnea Naloxone Aminophylline |
