| 摘要: |
| ［摘要］ 目的 探讨女方HIV阴性，而男方HIV阳性者夫妇或性伴侣经暴露前预防后行无保护性性交并妊娠的结果进行分析。方法 筛选15例符合入组标准并有妊娠生育期待的夫妇或性伴侣进行妊娠前咨询，女方需要知道HIV感染的危险可能降低，但不能排除。女方在首次授精前3个月左右开始自行记录基础体温，确定大致排卵时间。男方为HIV阳性患者，且CD+4 T淋巴细胞>250个/μl，病毒载量<50拷贝/ml。女性性伴侣在每个排卵周期授精2次，在无保护性性交前24 h服用齐多夫定（300 mg,2次/d），拉米夫定(300 mg,1次/d)，克力芝（500 mg,2次/d），第2次授精后24 h停止预防。如未妊娠重复上述周期。首次无保护性性交后1、3、6、12、18个月检测女方HIV抗体。结果 采用暴露前预防后无保护性性交15例夫妇或性伴侣妊娠生育7例，妊娠率47%（7/15）。15例入选病例研究终点均未发现女性HIV感染。结论 采用暴露前预防的方法可以降低未感染女性的易感性，为男性HIV感染者的生育期待提供了一种帮助。 |
| 关键词: 人类免疫缺陷病毒 暴露前预防 无保护性性交 妊娠 生育 |
| DOI：10.3969/j.issn.1674-3806.2010.11.22 |
| 分类号:R 512.91 |
| 基金项目: |
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| Analysis on pre-exposure prevention of 15 HIV-negative females before unprotected sexual intercourse and pregnancy |
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ZHANG Yong, LU Rui-chao, MENG Zhi-hao, et al.
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Guangxi Longtan Hospital,Liuzhou 545005,China
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| Abstract: |
| ［Abstract］ Objective To investigate the female pre-exposure prevention before unprotected intercourse and pregnancy of the couples or sexual partners in which the female with HIV-negative and the male with HIV-positive by using the method of pre-exposure prevention.Methods Fifteen couples or sexual partners with the expectation of pregnancy and childbearing will have pre-pregnancy consultation, and the female need to know that the risk of HIV infection may decrease, but cannot be excluded. The female should record their basal body temperature by themselves about 3 months before the first insemination, and identify the general ovulation date. The male were patients with HIV-positive, the CD+4 T lymphocytes> 250/μl, viral load< 50 copies/ml. The female sexual partners will be inseminated twice in each ovulation cycle, and will take Zidovudine(300 mg, b.i.d.); Lamivudine(300mg, q.d.), and Kaletra(500mg, b.i.d.) 24 hours before unprotected sexual intercourse, and discontinue prevention 24 hours after the second insemination. The above cycle will be repeated until pregnancy. After the first unprotected sexual intercourse, the female HIV antibody will be tested at month 1, 3, 6, 12 and 18.Results Seven out of 15 couples and sexual partners with unprotected sexual intercourse got pregnant and childbearing by using the method of pre-exposure prevention, and the pregnancy rate was 47% (7/15). No infection was found in females.Conclusion The method of pre-exposure prevention can decrease the vulnerability of uninfected females, and provide a help to the HIV infected males with childbearing expectation. |
| Key words: HIV Pre-exposure prevention Unprotected sexual intercourse Pregnancy Childbearing |
