| 摘要: |
| ［摘要］ 目的 研究依达拉奉联合早期高压氧疗对急性脑梗死（ACI）患者血清S-100β和神经特异性烯醇酶（NSE）水平和NIHSS评分的影响。方法 120例急性脑梗死患者随机分为依达拉奉治疗组60例和常规治疗组60例(予常规抗血小板聚集、改善脑循环、营养脑细胞等治疗)，依达拉奉治疗组在常规治疗的基础上予依达拉奉注射液及早期高压氧疗。两组均于治疗前、治疗后第3、7和14天检测静脉血中S-100β蛋白和神经特异性烯醇酶(NSE)的水平变化，治疗后第7、14、28天用美国国立卫生院神经功能缺损评分量表（National Institutes of Health stroke scale，NIHSS）评分并进行疗效评定。结果 依达拉奉组S-100β蛋白、NSE水平和NIHSS评分在治疗后均明显低于常规治疗组，疗效明显优于常规治疗组，差异有统计学意义。结论 依达拉奉联合早期高压氧疗可明显降低急性脑梗死患者血液中S-100β蛋白和NSE水平，治疗后NIHSS评分明显低于常规治疗组，疗效明显优于常规治疗组。 |
| 关键词: 急性脑梗死 依达拉奉 高压氧疗 S-100β蛋白 神经元特异性烯醇酶 |
| DOI：10.3969/j.issn.1674-3806.2011.03.10 |
| 分类号:R 743.33 |
| 基金项目: |
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| Influence of combination of edaravone with early hyperbaric oxygen therapy on serum levels of S-100β, NSE and NIHSS score of the patients with acute cerebral infarction |
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LI Shao-fa, LIANG Ke, LI Deng-xing, et al.
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The People′s Hospital of Baise City, Guangxi 533000，China
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| Abstract: |
| ［Abstract］ Objective To study the influence of the combination of edaravone with early hyperbaric oxygen therapy on serum levels of S-100β, neuro-specific endolase (NSE) and NIHSS score of the patients with acute cerebral infarction (ACI).Methods One hundred and twenty patients with ACI were randomly divided into two groups. Sixty patients in the controlled group were treated with routine regimen which was composed of inhibiting platelet aggregation, improving brain blood flow and metabolism of brain cells, etc. And 60 patients in the edaravone group were treated with edaravone combined with hyperbaric oxygen on the basis of routine regimen. Serum levels of S-100β and NSE were detected on the 3rd, 7th, 14th day after treatment. Otherwise, curative effect was evaluated with NIHSS score on the 7th, 14th, 28th day after treatment.Results Serum levels of S-100β and NSE, and NIHSS score in the patients of the edaravone group were obviously lower than those in the patients of controlled group.Conclusion The combination of edaravone with hyperbaric oxygen therapy can apparently lower serum levels of S-100β，NSE and NIHSS score in patients with ACI, and bring a better clinical outcome, as compared with the controlled group. |
| Key words: Acute cerebral infarction Edaravone Hyperbaric oxygen therapy S-100β Neuro-specific endolase |
