| 摘要: |
| ［摘要］ 线粒体在能量的产生和利用过程中起着核心作用，其功能紊乱会导致整个机体能量代谢的稳态被打破。而过氧化物酶增殖物激活受体γ辅助激活因子-1α（PGC-1α）作为一种转录辅助激活因子在调节线粒体能量代谢的过程中起着至关重要的作用。该文就PGC-1α在线粒体能量代谢中的作用以及通过在转基因动物体内过表达、基因敲除以及裸鼠模型的构建，探讨了PGC-1α对于线粒体能量代谢的影响。 |
| 关键词: PGC-1α 线粒体 能量代谢 |
| DOI：10.3969/j.issn.1674-3806.2011.08.42 |
| 分类号:Q 751 |
| 基金项目:国家自然科学基金项目（编号：30860113）；广西卫生厅重点科研课题项目（编号：桂卫重200736）；广西卫生厅自筹科研课题项目（编号：桂Z2007144） |
|
| Effect of PGC-1α on the mitochondria energy metabolism |
|
Effect of PGC-1α on the mitochondria energy metabolism
|
|
Department of Endocrinology，the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
|
| Abstract: |
| ［Abstract］ Mitochondria plays a central role in energy production and fuel utilization. Disordered mitochondrial function can impact whole-body metabolic homeostasis. As a transcriptional coactivator, peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is essential for the mitochondria energy metabolism. This review focuses on the role of PGC-1α in mitochondria energy metabolism and the effect on it after dealing with the PGC-1α transgenic mice of overexpression, null and knock-out. |
| Key words: PGC-1α Mitochondria Energy metabolism |
