| 摘要: |
| ［摘要］ 目的 观察前列腺素E1（PGE1）治疗糖尿病肾病Ⅲ期（DN-Ⅲ）的临床疗效。方法 35例糖尿病肾病（DN）患者予PGE1治疗2周，并观察24 h尿蛋白、24 h尿微量白蛋白、空腹血糖、餐后2 h血糖、血肌酐、血压的变化及不良反应等。结果 PGE1治疗2周后，24 h尿蛋白、24 h尿微量白蛋白较前均明显下降（P<0.01），其余检测指标虽较前降低，但差异无统计学意义（P>0.05）。患者治疗后无肝功能异常改变，治疗期间无皮疹、血管炎等不良反应发生。结论 PGE1可减轻DN-Ⅲ患者尿蛋白的排泄，延缓DN的发展和恶化。 |
| 关键词: 糖尿病肾病 前列腺素E1 蛋白尿 |
| DOI：10.3969/j.issn.1674-3806.2012.03.12 |
| 分类号:R 587 |
| 基金项目: |
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| Clinical observation of prostaglandin E1 in the treatment of diabetic nephropathy stage Ⅲ |
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CHEN Hao,HUANG Xuan-geng,HE Yu-ling
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Center of Metabolic Diabetes, the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To observe the effects of prostaglandin E1(PGE1) in the treatment of 35 diabetic patients with diabetic nephropathy stageⅢ.Methods Fasting blood-glucose（FBG）,2-hour postprandial blood glucose （PBG2h）,serum creatinine,blood pressure, 24-hour urinary protein(UPRO),24-hour microalbuminuria(UMALB), adverse reaction were observed after drip infusion of PGE1 for 2 weeks.Results As compared with pre-treatment,after treatment,24-hour urinary protein,24-hour microalbuminuria were reduced（P<0.01）,while there was no significant difference in the levels of FBG,PBG, systolic blood pressure （SBP）, diastolic blood pressure （DBP ）and serum creatinine（P>0.05）.And there were no skin rash, vasculitis, abnormal liver function and other adverse reaction in the patients during therapy.Conclusion PGE1 in the treatment of diabetic nephropathy stage Ⅲ can reduce urinary albumin excretion rate, delay the deterioration of DN. |
| Key words: Diabetic nephropathy Prostaglandin E1 Proteinuria |
