| 摘要: |
| ［摘要］ 目的 观察不同剂量低分子肝素(LMWH)治疗慢性肺源性心脏病（慢性肺心病）的疗效及副作用。方法 选取2007-04～2011-04救治的107例慢性肺心病急性加重期患者，并随机分为治疗一组（53例）和治疗二组（54例），两组患者均给予持续氧疗、抗感染、止咳、祛痰、平喘、扩血管、强心、利尿、维持水电解质平衡等综合治疗，治疗一组在此基础上加用LMWH 4250 U，皮下注射，1次/d，治疗二组加用LMWH 4250 U，皮下注射，2次/d（1次/12 h），两组均治疗7 d。比较两组治疗后的疗效和总有效率，并观察出血情况。结果 LMWH治疗后，两组的疗效和总有效率相近（P>0.05），均未发生全身出血情况，但治疗二组有4例出现注射部位出血。结论 在慢性肺心病急性加重期患者的治疗中，在治疗剂量固定情况下，采取1次/d给药与2次/d给药的疗效相同，且注射部位出血比例明显减少。 |
| 关键词: 低分子肝素 肺心病 不同剂量 |
| DOI：10.3969/j.issn.1674-3806.2012.03.13 |
| 分类号:R 563 |
| 基金项目: |
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| Clinical observation of different dosages of low molecular weight heparin in the treatment of cor pulmonale |
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ZHENG Shao-cheng,JIANG Hong-yan,BAI Ju,et al.
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Department of Internal Medicine,Guangtong Hospital of Chuxiong Autonomous Prefecture, Yunnan 651225,China
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| Abstract: |
| ［Abstract］ Objective To observe the effects and side effects in the treatment of cor pumonale with different daily dosages and amount of low molecular weight heparin(LMWH). Methods One hundred and seven acute phase patients with chronic pulmonary heart disease treated in our hospital from April, 2007 to April,2011 were randomly divided into: group 1 (n=53) and group 2 (n=54). The patients in both groups received the following comprehensive treatments: continuous Oxygen therapy, anti-infection, anti-cough,phlegm removing, asthma relief, blood vessels enlargement, heart strengthening, diureses and the balance of water and electrolyte maintenance. On this basis, Once a day the hypodermic injection of LMWH 4250 U was added to the patients of group 1 while adding twice a day (once per 12 hours) the hypodermic injection of LMWH 4250 U to the patients of group 2. The effective rates and total effective rates for both groups were compared and blood flow of the patients after seven-day treatment were observed. Results After using LMWH in the treatment,the effective rates and total effective rates for patients of both groups were similar, without obvious differences in statistics (P>0.05). In addition, none of the patients in both groups had a whole body bleeding symptom,but patients in group 2 had a higher bleeding rate in injection sites than patients in group 1. Conclusion In the treatment of the acute phase patients with chronic pulmonary heart disease, no matter once a day or twice a day,if the patients are given the fixed dosage of LMWH, the curative effect is the same and the bleeding rate in injection sites obviously reduces. |
| Key words: Low molecular weight heparin Cor pumonale Different dosages |
