| 摘要: |
| ［摘要］ 目的 探讨血浆N末端脑利钠肽前体（NT-ProBNP）及脑利钠肽（BNP）对毛细支气管炎合并急性充血性心力衰竭（AHF）早期诊断的临床意义。方法 选择2009-10～2011-03在青岛市妇女儿童医院住院的毛细支气管炎患儿60例为研究对象，随机分为对照组（未合并AHF）33例，AHF组（合并AHF）27例。采用酶联免疫吸附（ELISA）法检测血浆NT-ProBNP和BNP，并行心脏彩超多普勒(UCG)检测左室射血分数(LVEF)。结果 AHF组患儿血浆NT-ProBNP和BNP明显高于对照组（P<0.01），LVEF明显低于对照组（P<0.01）。AHF组患儿血浆NT-proBNP与LVEF呈显著负相关（r=-0.62，P<0.01），BNP与LVEF呈负相关（r=-0.39，P<0.05）。结论 血浆NT-proBNP和BNP浓度对于毛细支气管炎合并AHF的诊断具有较高的敏感性和特异性，可以作为其早期诊断指标。 |
| 关键词: 毛细支气管炎 心力衰竭 N末端脑利钠肽前体 脑利钠肽 |
| DOI：10.3969/j.issn.1674-3806.2012.08.12 |
| 分类号:R 725.6+4 |
| 基金项目: |
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| Clinic significance and variation of plasma N-terminal probrain natriuretic peptide precursor and brain natriuretic peptide in children with bronchiolitis and acute heart failure |
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ZHANG Yuan-feng,MA Shao-chun
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Qingdao Women and Children′s Hospital, Shandong 266034, China
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| Abstract: |
| ［Abstract］ Objective To investigate the clinical significance and diagnostic value of the concentrations of plasma NT-proBNP and BNP in children with bronchiolitis and acute congestive heart failure(AHF).Methods The concentration of plasma NT-proBNP and BNP were determined in the children with bronchiolitis (n=60,among the children 27 in AHF group,33 in controls) by enzyme-linked-immunosorbent serologic assay(ELISA), and LVEF were measured by two-dimensional echocardiography.Results The plasma concentrations of NT-proBNP and BNP were much higher in AHF children than those in controls(without AHF)(P<0.01). The NT-proBNP and BNP levels in AHF group had negative correlation with LVEF(r=-0.62,P<0.01; r=-0.39,P<0.05).Conclusion Plasma NT-proBNP and BNP level may be the more valuable laboratory plasma marker for prognosis and diagnosis of bronchiolitis with acute congestive heart failure. |
| Key words: Bronchiolitis Acute heart failure N-terminal probrain natriuretic peptide precursor Brain natriuretic peptide |
