| 摘要: |
| ［摘要］ 细胞凋亡程度的降低是肿瘤发生的主要机制，凋亡抑制蛋白在抑制细胞凋亡中起非常重要的作用。X连锁凋亡抑制蛋白(XIAP)是凋亡抑制蛋白(IAP)家族中的重要一员,XIAP通过抑制半胱天冬酶途径及参与其他细胞凋亡途径抑制细胞的凋亡。该文对XIAP的分子结构、表达调控、作用机制及其与消化系肿瘤的关系等方面的研究进展进行综述。 |
| 关键词: X连锁凋亡抑制蛋白 细胞凋亡 消化道肿瘤 |
| DOI：10.3969/j.issn.1674-3806.2012.10.34 |
| 分类号:R 57 |
| 基金项目: |
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| Advances in the research of the relation between XIAP and digestive system tumors |
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WANG Juan-juan, ZHANG Guo,ZHANG Fa-can
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Department of Gastroenterology, the People′s Hospital of Wuhan University,Hubei 430060,China
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| Abstract: |
| ［Abstract］ The decrease of apoptosis rate of cells is the main mechanism of tumors,The inhibitor of apoptosis protein plays important role in suppressing apoptosis of cells.X-linked inhibitor of apoptosis protein(XIAP) is one of the most important members of IAP family.It inhibits cell apoptosis mainly by inhibiting the caspases activation and interfering with other apoptotic pathway.This article reviews the recent advances in the research on its molecule structure,expression and function mechanism,relationship with digestive system tumors and so on. |
| Key words: X-linked inhibitor of apoptosis protein（XIAP） Apoptosis Digestive system tumor |
