| 摘要: |
| ［摘要］ 原发性肝癌（HCC）是世界最常见严重危害人群身心健康和生命安全的恶性肿瘤之一，其发病机制至今尚不明确。8-羟基脱氧鸟苷（8-OHdG）是活性氧自由基（ROS）造成的DNA氧化损伤修饰性产物之一，研究表明，8-OHdG与HCC发生发展有着很大的关联。该文对8-OHdG与HCC发生发展的研究现状进行综述。 |
| 关键词: 原发性肝癌 8-羟基脱氧鸟苷 氧化损伤 |
| DOI：10.3969/j.issn.1674-3806.2013.03.34 |
| 分类号:R 115 |
| 基金项目: |
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| Advances of 8-hydroxy-2’-deoxyguanosine expression in primary hepatocellular carcinoma |
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TANG Yi，LIU Li-li，TANG Yun-tian
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Guangxi Medical University, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Primary hepatocellular carcinoma（HCC）is one of the most common malignant tumors which is serious threatening people’s health,and its pathogenesis is still unclear so far. Research shows that 8-hydroxy-2′-deoxyguanosine(8-OHdG) play an important role in the carcinogenesis mechanism and development of HCC as the representative product of oxidative DNA damage.This paper reviews the present advances of research on 8-OHdG expression in HCC. |
| Key words: Primary hepatocellular carcinoma 8-hydroxy-2′-deoxyguanosine Oxidative DNA damage |
