| 摘要: |
| ［摘要］ 目的 探讨新生儿败血症的临床特点、病原菌构成及抗生素耐药性，指导临床诊治。方法 对2009-10～2013-01该院1 560例住院新生儿中血培养阳性的46例新生儿败血症患儿进行回顾性分析。结果 新生儿败血症临床表现缺乏特异性。血培养结果以葡萄球菌为主要致病菌，药敏试验发现大多数菌株对青霉素和氨苄西林耐药，对第一、二代头孢菌素类大部分耐药，对第三代头孢菌素类、舒巴坦、氨基糖甙类和喹诺酮类较敏感，对亚胺培南、万古霉素、替考拉宁高度敏感。结论 新生儿败血症临床表现缺乏特异性，病原菌以革兰氏阳性菌为主，监测病原菌耐药性变迁，根据药敏试验结果选用药物，对指导临床防治新生儿败血症具有重要的意义。 |
| 关键词: 新生儿 败血症 抗生素 敏感率 耐药率 |
| DOI：10.3969/j.issn.1674-3806.2013.06.14 |
| 分类号:R 72 |
| 基金项目: |
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| Analysis of clinical characteristics and pathogens in 46 neonates with septicemia |
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YANG Wan-qing
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Department of Pediatrics,the People’s Hospital of Sanjiang County,Guangxi 545500,China
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| Abstract: |
| ［Abstract］ Objective To explore the clinical features of neonates with septicemia, as well as the composition of pathogens and antibiotic resistance to guide clinical diagnosis and treatment.Methods A retrospective analysis was performed of 46 neonates with septicemia who had positive blood culture in 1 560 hospitalized neonates in our hospital from October 2009 to January 2013.Results The clinical manifestations of neonates with septicemia were lack of specificity. Blood culture results showed staphylococcus was the main pathogenic bacteria, the antibiotics susceptibility test showed that most strains were resistant against penicillin and ampicillin, and partial resistant against the first and second generation of cephalosporins. But it was sensitive to the third generation cephalosporins, sulbactam, aminoglycosides and quinolones, and was highly sensitive to imipenem, vancomycin, teicoplanin.Conclusion The clinical manifestations of neonates with septicemia were lack of specificity, the main of pathogens is gram-positive bacterium. Monitoring the alteration of drug resistance and choosing the antibiotics according to the results of the drugs susceptibility test, it have important significance for prevention and treatment of neonates with septicemia. |
| Key words: Neonate Septicemia Antibiotic Sensitivity rate Drug resistance |
