| 摘要: |
| ［摘要］ 目的 探讨鼻咽癌患者中性粒细胞（NEUT）、淋巴细胞计数(LY)与鼻咽癌放射性口腔黏膜炎程度和肿瘤消退率之间的关系以及放疗前后的动态变化规律。方法 选择首诊鼻咽癌患者68例为实验对象（观察组），采集入院时、放疗后第2、3、4、5、6、7周以及放疗结束、放疗后3个月患者血清标本，采用全自动血细胞分析仪分别检测患者外周血白细胞(WBC)、NEUT和中性粒细胞比例（NEUTR）、LY和淋巴细胞比例（LYR）、中性粒细胞和淋巴细胞比例（NLR）；另同期选择40名健康者作对照（对照组）。结果 鼻咽癌患者WBC、NEUT、NEUTR、LY、LYR及NLR与对照组比较差异无统计学意义(P均>0.05)；治疗后NEUTR和NLR明显高于治疗前(P均<0.01)；治疗后WBC、LY、LYR明显下降(P均<0.01)。放疗后第3、4、5、6、7周、放疗结束时及放疗后3个月患者的NEUTR均与同期口腔黏膜炎分级有关（P均<0.05）。治疗前后LYR变化与放疗结束时肿瘤消退率有关（P=0.048）。治疗期间口腔黏膜损伤程度与治疗结束时疗效有关（P=0.012）。结论 治疗期间监测中性粒细胞比例有助于判断放射性口腔黏膜损伤程度。治疗期间定期评价放射性口腔黏膜损伤程度，有助于预测肿瘤的近期疗效。 |
| 关键词: 放射性口腔黏膜炎 鼻咽癌 中性粒细胞比例 肿瘤消退率 |
| DOI：10.3969/j.issn.1674-3806.2014.01.08 |
| 分类号:R 739.6 |
| 基金项目: |
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| Relationship among neutrophils, lymphocytes, oral mucositis and tumor regression rate in patients with nasopharyngeal carcinoma: a prospective study |
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WENG Jing-jin, SI Yong-feng, QIN Yang-da, et al.
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Department of Otolaryngology Head and Neck Oncology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the relationship among neutrophils(NEUT), lymphocyte count(LY), radiation-induced oral mucositis and tumor regression rate in patients with nasopharyngeal carcinoma, as well as the dynamic changes before and after treatment.Methods Sixty-eight patients with nasopharyngeal carcinoma first diagnosed as experimental group, serum samples were collected at admission, two weeks, three weeks, four weeks, five weeks, six weeks, seven weeks after radiotherapy, the end of radiotherapy, 3 months after radiotherapy. Automatic blood cell analyzer was used to detect leukocytes(WBC), NEUT and neutrophil proportion(NEUTR), LY and lymphocyte proportion(LYR), proportion of neutrophils and lymphocytes(NLR), and 40 healthy people were enrolled in control group.Results WBC, NEUT, NEUTR, LY, LYR and NLR did not show significant difference between NPC patients and healthy people(all P>0.05). NEUTR and NLR after treatment were significantly higher than before treatment(all P<0.01); WBC, LY, LYR after treatment were decreased significantly(all P<0.01). NEUTR was correlated with the degree of oral mucositis during the same period at 3,4,5,6,7 weeks, the end of radiotherapy and 3 months after radiotherapy(all P<0.05). The changes in LYR was correlated with tumor regression rate(P=0.048). The degree of oral mucosal injury was correlated with tumor regression rate at the end of radiotherapy(P=0.012).Conclusion Monitoring the proportion of neutrophils can help judge the degree of radiation-induced oral mucosal injury during treatment. Periodic evaluation of radiation-induced oral mucosal injury during the treatment could help to predict short-term effect of NPC. |
| Key words: Radiation-induced oral mucositis Nasopharyngeal carcinoma Proportion of neutrophils Tumor regression rate |
