| 摘要: |
| ［摘要］ 目的 探讨贝前列腺素钠对早期糖尿病肾病患者尿白蛋白排泄率、血清胱抑素C及血管内皮功能的影响。方法 选择早期糖尿病肾病患者58例，按随机数字表法分为对照组30例和治疗组28例。对照组予低蛋白饮食、人胰岛素控制血糖、控制血压等常规治疗；治疗组在常规治疗的基础上使用贝前列腺素钠40 μg,口服3次/d，共使用12周。检测早期糖尿病肾病患者治疗前后糖化血红蛋白（HbA1c）、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、24 h尿白蛋白排泄率（24h UAER）、血清胱抑素C(Cys-C)、内生肌酐清除率（Ccr）、血内皮素-1（ET-1）水平，同时利用超声检测肱动脉血流介导的内皮依赖性血管舒张功能(FMD)。结果 两组患者治疗前后血糖、血压、血脂等指标比较差异无统计学意义（P>0.05），治疗组患者治疗后24 h UAER、血清Cys-C、ET-1较对照组显著降低，Ccr、内皮依赖性血管舒张功能（FMD）较对照组显著升高，差异均有统计学意义(P均<0.05)。结论 贝前列腺素钠有效地降低早期糖尿病肾病患者的血清Cys-C及24h UAER水平，并改善血管内皮功能。 |
| 关键词: 贝前列腺素钠 糖尿病肾病 内皮功能障碍 |
| DOI：10.3969/j.issn.1674-3806.2014.04.13 |
| 分类号:R 587.2 |
| 基金项目: |
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| Effect of the beraprost sodium on serum cystatin C, urinary microalbumin excretion rate and vascular endothelial function in patients with early diabetic nephropathy |
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LU Wei-bo，LI Shu-min，LV Yi-pei，et al.
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Department of Endocrinology，the Second People′s Hospital of Qinzhou，Guangxi 535000，China
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| Abstract: |
| ［Abstract］ Objective To investigate the effect of the beraprost sodium on serum cystatin C, urinary microalbumin excretion rate and vascular endothelial function in patients with early diabetic nephropathy.Methods Fifty-eight patients with early diabetic nephropathy were selected and randomly divided into 2 groups(control group with 30 cases and treatment group with 28 cases). Control group was treated with insulin,low-protein diet,control blood pressure; the treatment group was treated with beraprost sodium 40 μg tid on the basis of normal treatment for 12 weeks.The endothelium-dependent flow-mediated dilatation(FMD) of brachial artery was determined with ultrasound，and the levels of endothelin-1(ET-1), Glycated hemoglobin(HbA1c), triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), 24 h urinary albumin excretion rate(UAER), serum cystatin C(Cys-C), endogenous creatinine clearance(Ccr) were measured respectively before and after treatment.Results There was no statistically significant difference of blood sugar,blood pressure,blood lipid before and after treatment(P>0.05).After treatment，the levels of UAER, Cys-c and ET-1 in treatment group were significantly lower than those of the control group(P<0.05)，the levels of Ccr and FMD in treatment group were increased more significantly than control group(P<0.05).Conclusion The beraprost sodium can effectively reduce the levels of UAER, Cys-C and recovery renal vascular endothelial function in the patients with early diabetic nephropathy. |
| Key words: Beraprost sodium Diabetic nephropathies（DN） Endothelial dysfunction |
