| 摘要: |
| ［摘要］ 目的 探讨冠状动脉内注射半剂量替罗非班对老年急诊经皮冠状动脉介入治疗（PCI）心肌梗死患者术中慢血流的有效性及安全性。方法 98例老年急诊PCI术中出现慢血流的心肌梗死患者，随机分为A组和B组，各49例，分别于冠状动脉内给予5 μg/kg和10 μg/kg替罗非班，比较两组患者血浆C-反应蛋白、血清肌酸激酶同工酶和心肌肌钙蛋白I、心血管事件和术后3 d内出血情况。结果 入组时和术后第3天，两组患者血浆C-反应蛋白、血清肌酸激酶同工酶和心肌肌钙蛋白I差异无统计学意义(P>0.05)。两组患者主要心血管事件发生率差异无统计学意义(P>0.05)。两组患者无血红蛋白、血球压积和血小板计数下降，也未见过敏性反应等。A组患者出现轻度出血2例(4.08%)，B组3例(6.12%),两组比较差异无统计学意义(P>0.05)。结论 冠状动脉内注射半剂量替罗非班对老年急诊PCI心肌梗死患者术中慢血流临床疗效确切，具有安全高效和不良反应少等优点，值得在临床上推广应用。 |
| 关键词: 冠状动脉 盐酸替罗非班 急诊经皮冠状动脉介入治疗 急性心肌梗死 慢血流 |
| DOI：10.3969/j.issn.1674-3806.2014.09.09 |
| 分类号:R 54 |
| 基金项目: |
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| Safety and efficacy of intracoronary injection of half dose tirofiban for slow blood flow in elderly patients with myocardial infarction during emergency PCI operation |
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LIANG Kun
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The Third Department of Cardiovascular Diseases, the Fifth Affiliated Hospital of Zhengzhou University, Henan 450000, China
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| Abstract: |
| ［Abstract］ Objective To explore the safety and efficacy of intracoronary injection of half dose of tirofiban for the slow flow in elderly patients with acute myocardial infarction during emergency percutaneous coronary intervention(PCI) operation.Methods Ninety-eight elderly patients with myocardial infarction who had slow flow during emergency PCI operation were randomly divided into A group and B group, with 49 cases in each group, and were given 5 μg/kg and 10 μg/kg tirofiban in the coronary artery respectively. Between two groups the plasma C-reactive protein, serum creatine kinase MB and cardiac troponin I, cardiovascular events, bleeding with in 3 days after operation were compared.Results Baseline and third day after operation, the two groups had no statistically significant difference in serum C- reactive protein, serum creatine kinase MB and cardiac troponin I(P>0.05). Two groups had no decrease in hemoglobin, hematocrit and platelet counts, no allergic reaction was found. 2 cases of mild bleeding in A group(4.08%), 3 case of mild bleeding in B group(6.12%), no significant difference between two groups(P>0.05).Conclusion Intracoronary injection of half dose of tirofiban has the exact efficacy on slow flow of elderly myocardial infarctionin patients undergoing emergency PCI, and is safe and effective with less adverse reaction, and is worth of clinical application. |
| Key words: Coronary artery Tirofiban hydrochloride Emergency percutaneous coronary intervention(PCI) Acute myocardial infarction Slow flow |
