| 摘要: |
| ［摘要］ 目的 研究吸烟对男性精子形态、精子DNA完整率［用精子DNA断裂指数（DFI）表示］及顶体完整率的影响。方法 回顾性分析来该中心就诊的1 500例男性患者（1 300例吸烟者及200例未吸烟者），按每天吸烟量分为A1组500例，>20支/d；A2组600例，10～20支/d；A3组200例，1～9支/d。B组200例，0支/d，作为对照组。结果 精子正常形态随着每天吸烟量的增加而下降，各组间两两比较差异有统计学意义（P<0.05）。精子DNA完整率随着吸烟量的上升而降低(DFI升高)，各组间两两比较差异有统计学意义（P<0.05）。精子顶体完整率随吸烟量上升而下降，各组间两两比较差异有统计学意义（P<0.05）。结论 随着每天吸烟量增加精子正常形态、精子DNA完整率及精子顶体完整率均降低，不利于男性生殖健康。 |
| 关键词: 吸烟 男性不育症 精子形态 精子顶体完整率 精子DNA完整率 |
| DOI：10.3969/j.issn.1674-3806.2014.12.04 |
| 分类号:R 697 |
| 基金项目:广西卫生厅科研课题（编号：Z2014191） |
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| Effect of smoking on the male sperm morphology, sperm DNA integrity rate and sperm acrosome integrity rate |
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HE Yong-zhi, LI Da-wen, XIAO Xin, et al.
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Center for Reproductive Medicine and Genetics, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To study the effect of smoking on male sperm morphology,sperm DNA integrity rate ［DNA fragmentation index(DFI) was used for the evaluating］ and acrosome integrity rate.Methods A retrospective analysis was performed on 1 500 male patients come to our center for treatment（1 300 smokers and 200 non-smokers）. According to the daily smoking quantity the patients were divided into A1 group(500 cases):>20/day, A2 group(600 cases):10～20/day, A3 group(200 cases):1～9/day； and group B(200 cases):0/day(as the control group).Results The normal morphology rate of sperm decreased with the increase of daily smoking quantity, the pair comparison showed a significant differences between groups(P<0.05); the rate of sperm DNA integrity decreased with the rise of smoking(DFI will be increase), the pair comparison showed a significant differences between groups(P<0.05); the sperm acrosome integrity rate decreased with the increase of smoking quantity, the pair comparison showed a significant differences between groups(P<0.05).Conclusion With the increase of daily smoking quantity the rate of normal sperm morphology, sperm DNA integrity rate and sperm acrosome integrity rate are reduced,and is not good for male reproductive health. |
| Key words: Smoking Male infertility Sperm morphology Sperm acrosome integrity rate Sperm DNA integrity rate |
