| 摘要: |
| ［摘要］ 目的 探讨高血压患者血清超敏C反应蛋白（hsCRP）、血脂水平与左心室肥厚的关系。方法 收集高血压患者82例和对照组76名，测定hsCRP、空腹血糖(FPG)、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)；行心脏彩超检查并计算左室重量指数（LVMI）。结果 （1）高血压组hsCRP、LVMI和TG水平较对照组显著性增高［(5.13±2.36)mg/L vs (4.06±2.21)mg/L，P=0.006;(108.7±9.9)g/m2 vs (88.3±10.4)g/m2，P=0.000;(3.0±0.6)mmol/L vs (1.3±0.5)mmol/L，P=0.000］，而HDL-C显著性降低［(1.0±0.1)mmol/L vs (1.6±0.1)mmol/L，P=0.004］。（2）以LVMI为因变量的多元逐步回归分析显示，影响因素为hsCRP、收缩压（SBP）、TG和舒张压（DBP）。（3）高血压组按LVMI分为合并左心室肥厚组（A组）、无左心室肥厚组（B组），A组hsCRP较B组升高［(5.9±1.59)mg/L vs (5.0±2.23)mg/L，P=0.017］。结论 高血压患者血清hsCRP升高，合并左心室肥厚者升高更加明显。hsCRP、SBP、DBP和TG是高血压并左心室肥厚的影响因素。 |
| 关键词: 高血压 超敏C反应蛋白 血脂 左心室肥厚 |
| DOI：10.3969/j.issn.1674-3806.2015.02.11 |
| 分类号:R 544.1 |
| 基金项目: |
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| Relationship between hsCRP, serum lipid level and left ventricular hypertrophy in patients with hypertension |
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GUAN Wei
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Department of Cardiology, Central Hospital of Dongling District in Shenyang, Liaoning 110015, China
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| Abstract: |
| ［Abstract］ Objective To investigate the relationship between hsCRP, serum lipid level and left ventricular hypertrophy(LVH) in patients with hypertension.Methods Eighty-two patients with hypertension and 76 controls were included, hsCRP，FPG, TC, TG，HDL-C and LDL-C were measured. All subjects were taken echocardiography examination, then LVMI was calculated.Results (1)hsCRP, LVMI and TG in patients with hypertension were significantly higher than those in controls［(5.13±2.36)mg/L vs (4.06±2.21)mg/L，P=0.006;(108.7±9.9)g/m2 vs (88.3±10.4)g/m2，P=0.000; (3.0±0.6)mmol/L vs (1.3±0.5)mmol/L，P=0.000］，and HDL-C in patients with hypertension was significantly lower than that in controls［(1.0±0.1)mmol/L vs (1.6±0.1)mmol/L，P=0.004］. (2)In a multiple linear step-wise regression analysis, when taking LVMI as dependent variable and other factors as independent variables, we found that hsCRP, SBP, TG, and DBP were main determinants for LVMI. (3)Patients with hypertension were divided into other two subgroups according to LVMI:hypertension with LVH(group A) and hypertension without LVH(group B).hsCRP of group A was significantly higher than that of group B［(5.9±1.59)mg/L vs (5.0±2.23)mg/L，P=0.017］.Conclusion Inflammation exists in hypertension patients and becomes worse in hypertension patients with LVH.Inflammation and serum lipid level influence LVH in patients with hypertension. |
| Key words: Hypertension Hypersensitive C-reactive protein(hsCRP) Serum lipid Left ventricular hypertrophy(LVH) |
