| 摘要: |
| ［摘要］ 目的 探讨pN0胸段食管鳞癌术后复发、转移的高危因素，为术后采取合理辅助治疗提供临床依据，提高患者远期生存率。方法 回顾性分析福建省泉州市光前医院肿瘤外科2003-01～2010-12收治的76例pN0胸段食管鳞癌患者的临床资料，应用Cox比例风险回归模型分析术后3年内肿瘤复发、转移的危险因素。结果 术后3年内复发转移率为34.2%。单因素分析结果显示，肿瘤部位、pT分期、有无脉管癌栓与术后复发、转移相关（P<0.05）。多因素分析结果显示，食管中上段癌、pT3-4a、脉管癌栓是影响pN0胸段食管鳞癌术后复发、转移的独立风险因素。结论 胸中上段癌、pT3-4a、脉管癌栓是pN0胸段食管鳞癌术后复发、转移的独立风险因素，术后应给予积极辅助治疗。 |
| 关键词: 食管肿瘤 复发 转移 淋巴转移 |
| DOI：10.3969/j.issn.1674-3806.2015.02.13 |
| 分类号:R 735.1 |
| 基金项目: |
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| Study of risk factors for postoperative recurrence and metastasis of thoracic esophageal squamous carcinoma at pN0 stage |
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HUANG Xian-qiang
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Department of Surgical Oncology, Quanzhou Guangqian Hospital, Fujian 362321, China
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| Abstract: |
| ［Abstract］ Objective To explore the high-risk factors for postoperative recurrence and metastasis of thoracic esophageal squamous carcinoma during pN0 stage, and to provide rational postoperative adjuvant treatment and enhance long-term survival rate.Methods Clinical data of 76 patients diagnosed with thoracic esophageal squamous carcinoma(pN0 stage), admitted to Quanzhou Guangqian Hospital, Fujian Province from January 2003 to December 2010 were analyzed retrospectively. Cox proportional-hazards regression model was adopted to analyze the risk factors for recurrence and metastasis within postoperative 3 years.Results The recurrent metastasis rate was 34.2% within postoperative 3 years. Univariate analysis revealed the tumor location, pT staging and vascular thrombosis were correlated with postoperative recurrence and metastasis(all P<0.05). Multivariate analysis suggested that the middle and upper esophageal cancer, pT3-4a and vascular thrombosis were the independent risk factors for the postoperative recurrence and metastasis of thoracic esophageal squamous carcinoma during pN0 stage.Conclusion The middle and upper esophageal cancer, pT3-4a and vascular thrombosis act as independent risk factors for the postoperative recurrence and metastasis of thoracic esophageal squamous carcinoma during pN0 stage. Postoperative adjuvant treatment should be delivered actively. |
| Key words: Esophageal carcinoma Recurrence Metastasis Lymphatic metastasis |
