| 摘要: |
| ［摘要］ 目的 探讨氨氯地平降压治疗对老年轻中度高血压患者颈动脉内-中膜厚度（IMT）、肾功能及心脏结构与功能的影响。方法 选取40例轻中度老年原发性高血压患者，经氨氯地平（5～10 mg/d）治疗血压达标后，维持治疗。随访半年至一年，观察IMT、肾功能以及心脏结构与功能的变化。结果 高血压患者服用氨氯地平半年后，收缩压较服药前无明显下降（P>0.05），仅舒张压较治疗前显著下降（P<0.05）；治疗一年后，收缩压和舒张压较治疗前下降（P均<0.05）。24 h动态血压在服药半年及一年后均较治疗前有显著下降（P均<0.01）。与服药前相比较，治疗半年及一年后的IMT明显降低（P均<0.01）；尿β2-微球蛋白（β2M）、微量白蛋白（ALB）及血肌酐明显低于治疗前（P均<0.01）；左室舒张末内径（LVEDd）较治疗前有所增加，二尖瓣舒张期血流A峰速度(PAV)较治疗前有明显下降，E/A比值较治疗前有显著升高（P均<0.01）；左心室重量指数(LVMI)、室间隔厚度（IVST）、左室后壁厚度（PWT）、二尖瓣舒张期血流E峰速度(PEA)和左室射血分数（EF）的均值较治疗前均无明显差异。结论 服用氨氯地平降压治疗后，对颈动脉IMT、肾功能有明显改善作用，并且能改善心脏舒张功能，但对收缩功能无明显改善。 |
| 关键词: 氨氯地平 高血压 靶器官 |
| DOI：10.3969/j.issn.1674-3806.2015.06.01 |
| 分类号:R 544.1 |
| 基金项目:广西医疗卫生重点科研课题（编号：重200959） |
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| The effects of amlodipine on target organs in elderly patients with mild-to-moderate hypertension |
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WU Yin-xiong, WANG Xiao-yan, ZHANG Qin, et al.
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Cadre Integrated Ward, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To detect the changes of the carotid artery intima media thickness(IMT), renal function, cardiac structure and function in elderly patients with mild-to-moderate hypertension after antihypertensive treatment of amlodipine.Methods Forty elderly patients with mild to moderate primary hypertension were selected, and their parameters of IMT, renal function, cardiac structure and function were recorded with the follow-up of six to twelve months after the treatment of amlodipine.Results After treating with amlodipine for six months, the systolic blood pressure was not significantly decreased(P>0.05), while the diastolic blood pressure was significantly decreased(P<0.01); After one year′s treatment, the systolic blood pressure and diastolic blood pressure were both significanthy decreased(P<0.01). The 24 h ambulatory blood pressure significantly decreased after six months and one year′s treatment (P<0.01). After six months to one year′s treatment, IMT was significantly decreased(P<0.05); Urinary β2 microglobulin(β2M), albumin(ALB) and plasma creatinine were significantly decreased(P<0.01); The left ventricular end-diastolic dimension(LVEDd) and the E/A ratio were significantly increased, while the maximum diastolic mitral A-wave velocity measurement(PAV) was significantly decreased(P<0.01); The left ventricular mass index(LVMI), interventricular septum thickness(IVST), left ventricular posterior wall thickness(PWT), maximum diastolic mitral E-wave velocity measurement(PEV), and left ventricular ejection fraction(LVEF) were not significantly changed.Conclusion Antihypertensive therapy of amlodipine improves carotid IMT, renal function and heart diastolic function. |
| Key words: Amlodipine Hypertension Target organ |
