| 摘要: |
| ［摘要］ 目的 探讨高压氧对体外冲击波碎石术（extracorporeal shock wave lithotripsy,ESWL）性肾脏损伤家兔凝血功能及血细胞的影响。方法 选用12只家兔，随机分为两组（每组6只）：ESWL模型组（A组）给予ESWL冲击左肾1 500次（电容0.4 μF，电压18 kV）造成肾脏损伤，但未予高压氧治疗；实验组（B组）行ESWL冲击造成肾脏损伤后给予0.2 MPa(2.0 ATA)高压氧治疗，连续治疗7 d。治疗前、治疗后1 d、3 d、7 d分别测定血白细胞(white blood cell,WBC)、红细胞(red blood cell,RBC)、血小板(platelet，PLT)、活化部分凝血活酶时间（activated part clotting live enzyme time ，APTT）、凝血酶原时间(prothrombin time,PT）的变化。结果 HBO治疗前比较，两组各指标差异无统计学意义（P>0.05）；两组RBC在治疗后各时点无明显的变化（P>0.05）。在1 d、3 d，与A组相比，B组在高压氧治疗后能降低炎症反应时血WBC的水平，PT、APTT明显缩短，而PLT数量增加（P<0.05），但在7 d后能基本恢复到原来的水平（P>0.05）。结论 高压氧通过增加重要脏器供血供氧，在治疗ESWL性肾脏损伤中可以减少炎症反应，改善微循环，未诱发或加重ESWL术后肾脏的严重出血。 |
| 关键词: 体外冲击波碎石术 肾脏损伤 高压氧 凝血功能 血细胞 家兔 |
| DOI：10.3969/j.issn.1674-3806.2015.12.02 |
| 分类号:R 459.6 |
| 基金项目:广西科学研究与技术开发计划项目（编号：桂科攻1298003-5-4）；广西自然科学基金资助项目（编号：2014GXNSFAA118183）；广西卫计委科研课题(编号：Z2012262) |
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| The influence of hyperbaric on coagulation function and blood cells oxygen in rabbits with renal injury induced by ESWL |
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LI Ji-qing, CHEN Fu-chang, LIU Gang, et al.
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Department of Urology, the People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,China
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| Abstract: |
| ［Abstract］ Objective To evaluate the effect of hyperbaric oxygen on the coagulation function and blood cell changes in the treatment of rabbit renal injury induced by extracorporeal shock wave lithotripsy(ESWL).Methods Twelve rabbits were randomly divided into the control group and the experimental group. The control group were given ESWL impact on the left idney for 1 500 times(capacitance 0.4 μF, voltage 18 kV) to cause kidney damage, but without hyperbaric oxygen treatment. The experimental group receival hyperbaric oxygen treatment 0.2 MPa(2.0 ATA) for continuous 5 days. The changes in blood white blood cell(WBC), red blood cell(RBC), platelet(PLT), prothrombin time(PT), and activated part clotting live enzyme time(APTT) were observed before the treatment and 1, 3, 7 days after the treatment respectively.Methods There was no significant difference in RBC between the two groups after the hyperbaric oxygen treatment(HBOT)（P>0.05）. WBC, PT, APTT were significantly decreased in the experimental group at 1, 3 days after the HBOT compared with those in the control group, PLT were elevated in the experimental group（P<0.05）, and almost recovered back to their original levels 7 days after the HBOT(P>0.05).Conclusion Hyperbaric oxygen reduces inflammation reaction, but does not induce or aggravate renal severe bleeding in the treatment of renal injury induced by ESWL. By increasing blood flow and oxygen supply to the important visceral organs. |
| Key words: Extracorporeal shock wave lithotripsy（ESWL） Kidney damage Hyperbaric oxygen（HBO） Coagulation function Blood cell Rabbit |
