| 摘要: |
| ［摘要］ 目的 探讨2型糖尿病早期肾病的危险因素与防治策略。方法 以2型糖尿病早期肾病老年患者（DN组）73例，2型糖尿病无肾病患者（DM组）35例为研究对象，测定炎症指标血清炎症因子超敏C反应蛋白（hs-CRP）、肿瘤坏死因子α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）水平、生化指标空腹血糖（FBG）、餐后2 h血糖（PBG）、糖化血红蛋白（HbA1c）、血脂［总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）］、尿酸(UA)、空腹胰岛素（FINS）。计算胰岛素抵抗指数（HOMA-IR）、尿白蛋白排泄率（UAER）；测量身高、体重、血压。结果 DN组血清炎症因子hs-CRP、TNF-α、IL-6、IL-1β水平及LDL、UA、HbA1c、FINS、HOMA-IR比DM组升高（P<0.05）。相关分析显示，UAER与TNF-α、IL-6、HOMA-IR呈正相关（r=0.549、0.584、0.894，P<0.01）。结论 早期2型糖尿病肾病患者尿白蛋白排泄率与炎症状态、胰岛素抵抗相关。 |
| 关键词: 糖尿病肾病 白蛋白排泄率 炎症因子 胰岛素抵抗 |
| DOI：10.3969/j.issn.1674-3806.2015.12.03 |
| 分类号:R 587.2 |
| 基金项目:广西科学研究与技术开发计划课题（编号：桂科攻11138008） |
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| Correlation factors of urinary albumin excretion rate in elderly patients with diabetic nephropathy |
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LI Jian-ying
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The Second Department of Senior Cadre, the People′s Hospital of Guanxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To observe the risk factors and prevention strategies for the treatment of early type 2 diabetic nephropathy.Methods Seventy-three elderly patients with early type-2 diabetic nephropathy were taken as the research objects(DN group) and other matched 35 cases with diabetic but without nephropathy as the controls(DM group). The inflammation factors（hs-CRP, TNF-α, IL-6, IL-1β）, fasting blood-glucose（FBG）, 2-hour postprandial blood glucose（PBG）, glycosylated hemoglobin（HbA1c）, blood lipid levels（TC, TG, HDL, LDL）, Uric acid (UA), fasting insulin(FINS) and the insulin resistance index(HOMA-IR) were detected. Urinary albumin excretion rate(UAER) was tested in DN group. The data of height, weight and blood pressure were also collected.Methods The levels of inflammation factors hs-CRP, TNF-α, IL-6, IL-1β and LDL, UA, HbA1c, FINS and HOMA-IR were significantly more elevated in DN group than those in DM group（P<0.05）. The levels of UAER were positively related to TNF-α, IL-6 and HOMA-IR（r=0.549, 0.584, 0.894, P<0.01）.Conclusion UAER is associated with the levels of inflammatory and HOMA-IR in the elderly patients with early type-2 diabetic nephropathy. |
| Key words: Diabetic nephropathy UAER Inflammation factors Insulin resistance |
