| 摘要: |
| ［摘要］ 目的 探讨CDC2和PFTK1在食管鳞癌中的表达情况，并分析其与临床分期、病理分级和侵袭转移等恶性生物学特性的关系及临床意义。方法 采用免疫组织化学SP法检测CDC2及PFTK1蛋白在60例食管鳞癌组织及相应的癌旁组织中的表达情况。结果 CDC2在食管鳞癌组织及相应癌旁组织的阳性率分别为80.00%、50.00%，差异具有统计学意义(P<0.01)；PFTK1在食管鳞癌组织及相应癌旁组织的阳性率分别为53.33%、30.00%，差异具有统计学意义（P<0.05)。CDC2及PFTK1表达均与TNM分期、浸润深度、淋巴结转移有关（P<0.05)。CDC2与PFTK1在食管鳞癌组织中的表达呈正相关(r=0.367,P=0.004)。结论 CDC2及PFTK1可能共同参与食管鳞癌的发生、发展。 |
| 关键词: CDC2 PFTK1 食管鳞癌 |
| DOI：10.3969/j.issn.1674-3806.2015.12.10 |
| 分类号:R 735.1 |
| 基金项目: |
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| Expressions of CDC2 and PFTK1 in esophageal squamous cell carcinoma and their clinical significances |
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SUN Jiang-tao, CHU Xu, CHEN Jian-min, et al.
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Department of Oncology, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, China
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| Abstract: |
| ［Abstract］ Objective To investigate the expressions of CDC2 and PFTK1 in esophageal squamous cell carcinoma and to analyze their relationship with biological characteristics of malignant, clinical stage, pathological grade and invasion and metastasis of ESCC and clinical significances.Methods The expressions of CDC2 and PFTK1 in esophageal squamous cell carcinoma tissues and their para-cancerous tissues were detected by immunohistochemical SP method.Methods The positive rates of CDC2 in esophageal squamous cell carcinoma, para-cancerous tissues were 80.00%, 50.00%(P<0.05), the differences were statistically significant; the positive rates of PFTK1 in esophageal squamous cell carcinoma, para-cancerous tissues were 53.33%, 30.00%(P<0.05), the differences were statistically significant. The expressions of CDC2 and PFTK1 were associated with TNM stage, invasive depth and lymph node metastasis(P<0.05). There was positive correlation between the expressions of CDC2 and PFTK1 in esophageal squamous cell carcinoma(r=0.367, P=0.004).Conclusion CDC2 and PFTK1 may be involved in the occurrence and development of esophageal squamous carcinom. |
| Key words: CDC2 PFTK1 Esophageal squamous cell carcinoma |
