| 摘要: |
| ［摘要］ 目的 探讨B细胞特异性莫洛尼白血病毒插入位点1(Bmi-1)的表达与非小细胞肺癌（non-small cell lung cancer，NSCLC）的关系。方法 检索Pubmed、Embase、Web of Science、中国期刊全文数据库（CNKI）、万方和维普数据库，检索日期自数据库建库至2015-03，同时采用文献追溯、手工检索等方法查找有关Bmi-1与NSCLC的中英文病例-对照研究，按照已拟定的纳入与排除标准筛选符合系统性评价标准的研究。提取Bmi-1与临床病理特征相关数据，如性别、年龄、病理组织学分型等，应用RevMan5.2软件进行数据分析。结果 最终纳入11篇病例-对照研究，其中NSCLC组697例，对照组504例，meta分析结果显示Bmi-1在NSCLC组织中的表达水平明显高于对照组(P<0.01)；Bmi-1表达与NSCLC分化程度、淋巴结转移、TNM分期相关(P均<0.01)，但与其病理分型、肿瘤大小无明显相关(P均>0.05)。结论 Bmi-1表达水平的检测可能成为NSCLC早期诊断、预后判断及疗效监测的新方法。 |
| 关键词: 非小细胞肺癌 B细胞特异性莫洛尼白血病毒插入位点1 meta分析 |
| DOI：10.3969/j.issn.1674-3806.2015.12.12 |
| 分类号:R 734.2 |
| 基金项目: |
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| Meta-analysis of Bmi-1 expression and clinical significance in non-small cell lung cancer |
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LAI Xiang-li, FENG Guo-sheng, GAO Shan
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Department of Chemotherapy, the People＇ s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
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| Abstract: |
| ［Abstract］ Objective To investigate the association between the expression of B-cell specific moloney leukemia virus insertion site 1(Bmi-1) and non-small cell lung cancer(NSCLC).Methods According to the inclusion and exclusion criteria, We independently searched the case-control studies of Bmi-1 and non-small cell lung cancer that published in Pubmed, Embase, Web of Science, CNKI, Wanfang database and VIP database both in Chinese and English until March 2015, and a retrospective review of the literatures was analyzed. We extracted the clinic pathological features of NSCLC relevant to Bmi-1, such as gender, age and histological type. All statistical analysis was performed by the RevMan5.2 Meta-analysis software.Methods Eleven case-control studies were eventually recruited, including 697 cases of NSCLC patients and 504 cases of the control group. Meta-analysis indicated that the expression level of Bmi-1 in NSCLC was significantly higher than that in the control group(P<0.01). The expression level of Bmi-1 in NSCLC was closely correlated with the degree of differentiation and the lymph node metastasis(P<0.01), but not correlated with the pathological types(P>0.05).Conclusion The detection of Bmi-1 expression level may become a new method for the earlier diagnosis, prognosis and monitoring curative effects of NSCLC. |
| Key words: Non-small cell lung carcinoma(NSCLC) B-cell specific moloney leukemia virus insertion site 1(Bmi-1) Meta-analysis |
