| 摘要: |
| ［摘要］ 目的 探讨支气管哮喘急性发作期患者血清超敏C-反应蛋白（hs-CRP）的水平及临床意义。方法 将收治的85例支气管哮喘急性加重期患者作为哮喘急性组，选择48例支气管哮喘缓解期患者作为哮喘缓解组，46名健康人作为对照组，分别测定三组研究对象血清hs-CRP以及肺功能指标。结果 三组研究对象间hs-CRP、FEV1%、FEV1/FVC%比较差异均有统计学意义（P<0.05），其中急性组和缓解组hs-CRP水平均比对照组明显增高，而FEV1%、FEV1/FVC%则明显降低（P<0.05）；急性组hs-CRP水平比缓解组明显增高，而FEV1%、FEV1/FVC%明显降低（P<0.05）。随着哮喘严重程度的提高，hs-CRP水平也随之增高（P<0.05）。急性发作期患者血清hs-CRP水平与FEV1%、FEV1/FVC%均呈明显负相关（P<0.05）；而缓解期患者血清hs-CRP水平与FEV1%、FEV1/FVC%均无相关性（P>0.05）。结论 气管哮喘急性加重期患者血清hs-CRP水平明显增高，而且hs-CRP水平与患者肺功能密切相关。 |
| 关键词: 支气管哮喘 急性发作期 超敏C-反应蛋白 肺功能 |
| DOI：10.3969/j.issn.1674-3806.2016.01.15 |
| 分类号:R 562.2+5 |
| 基金项目: |
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| The levels and signigicance of serum high-sensitivity C-reactive protein in asthmatic patients during acute attack |
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MO Yan-ping
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Department of Respiratory Medicine, the Center Hospital of Lizhou Railway Bureau, Guangxi 545007, China
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| Abstract: |
| ［Abstract］ Objective To explore the levels and signigicance of serum high-sensitivity C-reactive protein(hs-CRP) in asthmatic patients during acute attack.Methods Eighty-five patients with asthma during acute attack period in our department were taken as the acute group and other 48 patients with asthma during remission period as the remission group, and 46 healthy people were taken as the control group. The serum hs-CRP and pulmonary function index were determined in the three groups.Results There hs-CRP, FEV1% and FEV1/FVC% among the three groups were significant differences(P<0.05). The levels of hs-CRP in the acute group and the remission group were signigicantly higher than that in the control group, and the FEV1% and FEV1/FVC% were signigicantly lower than those in the control group(P<0.05). The level of hs-CRP of the acute group was signigicantly higher than that of the remission group, and the FEV1% and FEV1/FVC% in the acute group were signigicant lower than those in the remission group(P<0.05). With the increase of asthma severity, the level of hs-CRP increased(P<0.05). The level of serum hs-CRP was negatively associated with FEV1% and FEV1/FVC% in the acute group(P<0.05), but the level of serum hs-CRP was not associated with FEV1% and FEV1/FVC% in the remission group(P>0.05).Conclusion The level of serum hs-CRP is signigicantly increased in asthmatic patients during acute attack, and the level of serum hs-CRP is associated with pulmonary function index in asthmatic patients during acute attack. |
| Key words: Asthmatic Acute attack period High-sensitivity C-reactive protein(hs-CRP) Pulmonary function |
