| 摘要: |
| ［摘要］ 目的 探讨TCF21与Caspase-3在非小细胞肺癌(NSCLC)组织中的表达及意义。方法 收集广西宾阳县人民医院2013-01～2015-01外科手术切除的NSCLC标本共44例（含癌及癌旁组织）。采用实时荧光定量PCR(RT-PCR)技术检测TCF21与Caspase-3在肺癌组织及正常组织中的表达，分析NSCLC组织中TCF21与Caspase-3的表达及与临床分期的关系。结果 TCF21和Caspase-3在NSCLC组织中表达明显低于癌旁正常肺组织［(0.36±0.70） vs （1.00±0.00）、（0.62±0.56） vs （1.00±0.00）,P<0.01］,且二者在肺癌TNM Ⅲ期中的表达较Ⅰ+Ⅱ期的表达量明显降低［（0.05±0.06） vs （0.48±0.79）、（0.17±0.20） vs （0.78±0.56），P<0.01］。TCF21和Caspase-3在NSCLC组织中的表达呈正相关。结论 TCF21和Caspase-3低表达可能促进了肿瘤的恶性增殖及转移，联合检测TCF21和Caspase-3对判断NSCLC恶性程度、转移潜能及预后有重要的临床意义。 |
| 关键词: 转录因子21 Caspase-3 非小细胞肺癌 凋亡 |
| DOI：10.3969/j.issn.1674-3806.2016.04.11 |
| 分类号:R 734 |
| 基金项目:南宁市科研项目（编号：20133195） |
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| The expressions of TCF21 and Caspase-3 and their clinical significances in non-small cell lung cancer |
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LI Shou-nan, XIAN Lei, WU Zheng-qiu, et al.
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Department of Cardiothoracic Surgery, the People′s Hospital of Binyang County, Guangxi 530405, China
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| Abstract: |
| ［Abstract］ Objective To investigate the relationship between the expressions of TCF21 and Caspase-3 and the clinicopathological features in non-small cell lung cancer(NSCLC).Methods 44 samples coming from both adjacent and cancer tissues were collected from the People′s Hospital of Binyang County in Guangxi during 2013 to 2015. Real-time PCR(RT-PCR) was used to assay the expressions of TCF21 and Caspase-3 in lung cancer and normal tissues, and the relationship between the expressions of TCF21 and Caspase-3 and the clinicopathological features in NSCLC was analyzed.Results The expressions of TCF21 and Caspase-3 in NSCLC tissues were significantly lower than those in the matched normal lung tissues［(0.36±0.70） vs （1.00±0.00）, （0.62±0.56） vs （1.00±0.00）, P<0. 05］. The levels of TCF21 and Caspase-3 expressions were significantly lower in the mid-term lung cancer TNM Ⅲ than those in TNM Ⅰ+Ⅱ［（0.05±0.06） vs （0.48±0.79）, （0.17±0.20） vs （0.78±0.56）, P<0.01］. There was a positive correlation between the expressions of TCF21 and Caspase-3 in NSCLC. Conclusion The low expressions of TCF21 and Caspase-3 may aggravate the malignant hyperplasy and metastasis of tumor, combined detection of the expressions of TCF21 and Caspase-3 plays an important role in evaluating the degree of malignancy, and predicting the potential metastasis and prognosis of NSCLC. |
| Key words: Transcription factor 21(TCF21) Caspase-3 Non-small cell lung cancer(NSCLC) Apoptosis |
