| 摘要: |
| ［摘要］ 了解巴氏水肿胎的血红蛋白电泳特点。方法 回顾分析用毛细管电泳仪检出的巴氏水肿胎39例，并进行地贫基因分析。分别按照孕24～28周、孕29～32周、孕33～38周分组进行统计分析。结果 HbBart′s和HbPortland含量在孕24～28周、孕29～32周、孕33～38周组中分别是（78.2±2.5）%、（14.3±2.5）%、（79.9±4.8）%和（12.7±4.0）%、（84.0±2.1）%和（9.3±2.5）%，三组比较，HbBart′s和HbPortland含量差异有统计学意义（P<0.05）。基因型除了1例为泰国型合并东南亚型缺失外，余均为东南亚型缺失纯合子。结论 巴氏水肿胎血红蛋白主要成分是HbBart′s和HbPortland，而毛细管电泳可作为快速诊断巴氏水肿胎的有效手段。 |
| 关键词: 巴氏水肿胎 毛细管电泳 地中海贫血 |
| DOI：10.3969/j.issn.1674-3806.2016.07.06 |
| 分类号:R 446 |
| 基金项目:广西卫计委科研课题（编号：Z2013353） |
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| Characteristics of hemoglobin electrophoresis in HbBart′s hydrops syndrome |
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WEI Jin-hua, WAN Li-kai, LI You-qiong, et al.
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Department of Clinical Laboratory, Maternity and Child Healthcare Hospital of Long′an County, Guangxi 532700, China
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| Abstract: |
| ［Abstract］ Objective To study the characteristics of hemoglobin electrophoresis in HbBart′s hydrops syndrome.Methods HbBart′s hydrops syndrome was checked out in 39 patients by capillary electrophoresis, and their thalassemia genes were analyzed. The patients were divided into three groups according to different gestational weeks: 24～28 pregnant weeks group, 29～32 pregnant weeks group and 33～38 pregnant weeks group. The contects of HbBart′s and HbPortland were detected and compared among the three groups.Results The values of HbBart′s and HbPortland were （78.2±2.5）%,（14.3±2.5）%,（79.9±4.8）% and （12.7±4.0）%,（84.0±2.1）%,（9.3±2.5）% in the 24～28 pregnant weeks group, the 29～32 pregnant weeks group, and the 33～38 pregnant weeks group, respectively. There were significant differences in the contects of HbBart′s and HbPortland among the three groups(P<0.05). All cases were homozygous Southeast Asian(SEA) type deletion except that one was Thailand combined SEA type deletion.Conclusion HbBart′s and HbPortland are the main components of HbBart′s hydrops syndrome, and capillary electrophoresis is a diagnostic method for HbBart′s hydrops syndrome. |
| Key words: HbBart′s hydrops syndrome Capillary electrophoresis Thalassemia |
