| 摘要: |
| ［摘要］ 目的 探讨不同剂量肾上腺皮质激素对小儿急重症感染的干预作用。方法 选取2012-03～2015-03该院收治的90例急重症感染患儿为研究对象，均接受抗生素联合肾上腺皮质激素治疗，根据肾上腺皮质激素用药剂量不同将其分为大剂量组（6～10 mg·kg-1·d-1）、中剂量组（3～5 mg·kg-1·d-1）和小剂量组（1～2 mg·kg-1·d-1）各30例，比较三组患儿体温恢复正常时间、并发症发生率及治疗前后C反应蛋白（CRP）、血沉等指标。结果 三组用药后CRP、白细胞（WBC）、血沉较用药前均显著降低（P<0.05），但三组间比较差异无统计学意义（P>0.05）。大剂量组体温恢复时间短于中剂量组和小剂量组，并发症发生率高于中剂量组和小剂量组，差异有统计学意义（P<0.05）。结论 肾上腺皮质激素能明显减轻小儿急重症感染炎症反应，大剂量用药患儿体温恢复时间短，但并发症多，小剂量组无并发症但体温恢复正常时间长，建议行中剂量肾上腺皮质激素干预。 |
| 关键词: 肾上腺皮质激素 急重症感染 不同剂量 |
| DOI：10.3969/j.issn.1674-3806.2016.07.18 |
| 分类号:R 586 |
| 基金项目: |
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| Effects of different doses of adrenal cortical hormone on acute severe infection in children |
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YANG Pei-na
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Department of Pediatrics, Maternal and Child Health Hospital of Anyang City, Henan 455000, China
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| Abstract: |
| ［Abstract］ Objective To investigate the effects of different doses of adrenal cortex hormone on acute severe infection in children.Methods Ninety children with acute severe infection treated in our hospital from March 2012 to March 2015 were collected as the study objects. All patients were treated with antibiotics combined with adrenal cortical hormone. According to different doses of adrenal cortical hormone, the patients were divided into the high-dose group(6～10 mg·kg-1·d-1), middle-dose group(3～5 mg·kg-1·d-1) and low-dose group(1～2 mg·kg-1·d-1), with 30 cases in each group. The time of body temperature recovery, the incidence of complications, CRP, erythrocyte sedimentation and the other indexes were compared among the three groups before and after the treatment.Results CRP, WBC and erythrocyte sedimentation in the three groups after the treatment were significantly lower than those before the treatment(P<0.05), but the differences were not significant among the three groups after the treatment(P>0.05). The time of body temperature recovery and the incidence of complications in the high-dose group were （2.8±0.2）d and 26.7%, respectively. Compared with those in the middle-dose group and the low-dose group, the differences were statistically significant(P<0.05).Conclusion Adrenal cortical hormone can significantly reduce the inflammatory reactions in children with acute severe infection. Middle dose of adrenal cortical hormone is recommended. |
| Key words: Adrenal cortex hormone Acute and severe infection Different doses |
