| 摘要: |
| ［摘要］ 目的 探讨非那雄胺联用氨甲环酸对控制开放性耻骨后前列腺癌根治术（ORRP）患者手术出血风险的效果。方法 选取该院外科68例接受ORRP手术的患者，用随机数字表法将其分为观察组和对照组，每组34例。观察组在常规术前准备基础上于术前2周开始至术后3 d内口服非那雄胺，并在术中和术后3 d内静脉应用氨甲环酸；对照组按常规进行术前准备和术后处理。记录并比较两组术中出血量、出血指数、出血强度及术后3 d内每日平均出血量、膀胱冲洗液转清时间。结果 观察组术中出血量、出血指数、出血强度及术后3 d内平均日出血量等4项指标均明显低于对照组（P<0.05）；观察组术后膀胱冲洗液转清时间亦短于对照组（P<0.05）。结论 非那雄胺联用氨甲环酸可以有效控制ORRP患者手术出血的风险。 |
| 关键词: 非那雄胺 氨甲环酸 前列腺癌根治术 手术出血 |
| DOI：10.3969/j.issn.1674-3806.2016.08.14 |
| 分类号:R 737.25 |
| 基金项目: |
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| Randomized and tontrolled trial on bleeding risk of finasteride combined with tranexamic acid to control open retropubic radical prostatectomy |
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DING Cai-xue
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Randomized and tontrolled trial on bleeding risk of finasteride combined with tranexamic acid to control open retropubic radical prostatectomy
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| Abstract: |
| ［Abstract］ Objective To explore the surgical bleeding risk of finasteride combined with tranexamic acid on the patients undergoing open retropubic radical prostatectomy(ORRP).Methods Sixty-eight patients undergoing ORRP in Gongan Hospital of Traditional Chinese Medicine were randomly divided into the observation group and the control group, with 34 cases in each group. The patients in the observation group were orally administered with finasteride two weeks before the operation and 3 days after the operation on basis of the routine preoperative preparations, and were subjected to intravenous application of tranexamic acid during the operation and 3 days after the operation. The patients in the control group received the routine preoperative preparation and postoperative treatment. The bleeding amount, bleeding index, bleeding intensity, average daily blood loss and the time of washing bladder within 3 days after the operation were compared between the two groups.Results All the above indexes of the observation group were significantly lower or shorter than those of the control group(P<0.05).Conclusion Finasteride combined with tranexamic acid can effectively reduce the bleeding risk in the patients undergoing ORRP. |
| Key words: Finasteride Tranexamic acid Radical prostatectomy Surgical bleeding |
