| 摘要: |
| ［摘要］ 目的 分析重症手足口病患儿合并心衰的危险因素及米力农联合美托洛尔治疗效果。方法 收集2012-04～2015-04该院收治的98例重症手足口病患儿的临床资料，其中并发心衰15例，无心衰83例，分析重症手足口病合并心衰的相关危险因素，观察米力农联合美托洛尔治疗重症手足口病合并心衰患儿的临床效果。结果 多因素分析结果显示，呼吸急促、心率上升、血压上升、EV71感染为重症手足口病患儿发生心衰的独立危险因素（P<0.05）；治疗后，患儿心输出量（CO）、左心室射血分数（LVEF）上升，与治疗前比较差异有统计学意义（P<0.05）。结论 呼吸急促、血流动力学改变、EV71感染为重症手足口病患儿发生心衰的独立危险因素，采用米力农联合美托洛尔治疗重症手足口病合并心衰患儿，可改善其心功能，提升机体免疫功能。 |
| 关键词: 重症手足口病 心衰 危险因素 米力农 美托洛尔 |
| DOI：10.3969/j.issn.1674-3806.2016.10.18 |
| 分类号:R 725.1 |
| 基金项目: |
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| Risk factors of severe HFMD with heart failure in children and the curative effect of milrinone combined with metoprolol |
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WANG Li-jun
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Department of Pediatrics, Zhoukou Hospital of Traditional Chinese Medicine, Henan 466000, China
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| Abstract: |
| ［Abstract］ Objective To analyze the risk factors of severe hand-foot-mouth disease(HFMD) with heart failure in children and the curative effect of milrinone combined with metoprolol on HFMD.Methods The clinical data of 98 children with severe HFMD in our hospital from April 2012 to April 2015 were collected, including 15 cases complicated with heart failure and 83 cases without complications. The risk factors of severe HFMD with heart failure were analyzed and the clinical effect of milrinone combined with metoprolol on severe HFMD was observed.Results Multiple factors analysis showed that the independent risk factors of heart failure in children with severe HFMD were tachypnea, hemodynamic changes of blood pressure and heart rate and EV71 infections(P<0.05). After the treatment, LVEF and CO increased. Compared with those before the treatment, the differences were statistically significant(P<0.05).Conclusion Tachypnea, hemodynamic changes and EV71 infection are the independent risk factors for heart failure in the children with severe HFMD. Milrinone combined with metoprolol can improve the cardiac function and enhance the body′s immune function in children with severe HFMD. |
| Key words: Severe hand-foot-mouth disease(HFMD) Heart failure Risk factor Milrinone Metoprolol |
